Activation of thin-fiber muscle afferents by a P2X agonist in cats

Ramy L. Hanna, Marc P Kaufman

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of α,β-methylene ATP (50 μg/kg) was examined in decerebrate cats. We found that this P2X3 agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by α,β -methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2′,4′-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by α,β -methylene ATP. We conclude that P2X3 agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.

Original languageEnglish (US)
Pages (from-to)1166-1169
Number of pages4
JournalJournal of Applied Physiology
Volume96
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • Adenosine 5′-triphosphate
  • Group III afferents
  • Group IV afferents
  • Metaboreflex
  • Pressor response
  • Purines

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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