Activation of Salmonella-specific immune responses in the intestinal mucosa

Aparna Srinivasan, Stephen J Mcsorley

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The mammalian immune response to Salmonella has long been a subject of scientific study. Indeed, many of the general aspects of bacterial pathogenesis and host immune defense have been well described. However, a lack of clarity remains concerning important aspects of the host immune response to Salmonella, particularly with regard to the induction of an immune response in the intestinal mucosa. A major limitation has been the general lack of knowledge about specific antigenic targets that are recognized by both the innate and adaptive immune response in the intestine. Progress towards the identification of these targets is critical for the development of a detailed model of immunity to Salmonella and will lead to a better understanding of mucosal immune responses to other intracellular pathogens.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume54
Issue number1
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Intestinal Mucosa
Salmonella
Mucosal Immunity
Adaptive Immunity
Innate Immunity
Intestines
Immunity

Keywords

  • Immune responses
  • Intestinal mucosa
  • Salmonella

ASJC Scopus subject areas

  • Immunology

Cite this

Activation of Salmonella-specific immune responses in the intestinal mucosa. / Srinivasan, Aparna; Mcsorley, Stephen J.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 54, No. 1, 02.2006, p. 25-31.

Research output: Contribution to journalArticle

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