Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative

Carolyn M. Sawyer, Mirela Iodi Carstens, Christopher T. Simons, Jay Slack, T. Scott McCluskey, Stefan Furrer, Earl Carstens

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The enigmatic sensation of tingle involves the activation of primary sensory neurons by hydroxy-α-sanshool, a tingly agent in Szechuan peppers, by inhibiting two-pore potassium channels. Central mechanisms mediating tingle sensation are unknown. We investigated whether a stable derivative of sanshool - isobutylalkenyl amide (IBA) - excites wide-dynamic range (WDR) spinal neurons that participate in transmission of chemesthetic information from the skin. In anesthetized rats, the majority of WDR and low-threshold units responded to intradermal injection of IBA in a dose-related manner over a >5-min time course and exhibited tachyphylaxis at higher concentrations (1 and 10%). Almost all WDR and low-threshold units additionally responded to the pungent agents mustard oil (allyl isothiocyanate) and/or capsaicin, prompting reclassification of the low-threshold cells as WDR. The results are discussed in terms of the functional role of WDR neurons in mediating tingle sensation.

Original languageEnglish (US)
Pages (from-to)1742-1748
Number of pages7
JournalJournal of Neurophysiology
Volume101
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Neurons
Amides
Tachyphylaxis
Intradermal Injections
Capsaicin
Potassium Channels
Sensory Receptor Cells
Skin
sanshool
allyl isothiocyanate
mustard oil

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Sawyer, C. M., Carstens, M. I., Simons, C. T., Slack, J., McCluskey, T. S., Furrer, S., & Carstens, E. (2009). Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. Journal of Neurophysiology, 101(4), 1742-1748. https://doi.org/10.1152/jn.91311.2008

Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. / Sawyer, Carolyn M.; Carstens, Mirela Iodi; Simons, Christopher T.; Slack, Jay; McCluskey, T. Scott; Furrer, Stefan; Carstens, Earl.

In: Journal of Neurophysiology, Vol. 101, No. 4, 04.2009, p. 1742-1748.

Research output: Contribution to journalArticle

Sawyer, CM, Carstens, MI, Simons, CT, Slack, J, McCluskey, TS, Furrer, S & Carstens, E 2009, 'Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative', Journal of Neurophysiology, vol. 101, no. 4, pp. 1742-1748. https://doi.org/10.1152/jn.91311.2008
Sawyer CM, Carstens MI, Simons CT, Slack J, McCluskey TS, Furrer S et al. Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. Journal of Neurophysiology. 2009 Apr;101(4):1742-1748. https://doi.org/10.1152/jn.91311.2008
Sawyer, Carolyn M. ; Carstens, Mirela Iodi ; Simons, Christopher T. ; Slack, Jay ; McCluskey, T. Scott ; Furrer, Stefan ; Carstens, Earl. / Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. In: Journal of Neurophysiology. 2009 ; Vol. 101, No. 4. pp. 1742-1748.
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