Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative

Carolyn M. Sawyer, Mirela Iodi Carstens, Christopher T. Simons, Jay Slack, T. Scott McCluskey, Stefan Furrer, Earl Carstens

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Abstract

The enigmatic sensation of tingle involves the activation of primary sensory neurons by hydroxy-α-sanshool, a tingly agent in Szechuan peppers, by inhibiting two-pore potassium channels. Central mechanisms mediating tingle sensation are unknown. We investigated whether a stable derivative of sanshool - isobutylalkenyl amide (IBA) - excites wide-dynamic range (WDR) spinal neurons that participate in transmission of chemesthetic information from the skin. In anesthetized rats, the majority of WDR and low-threshold units responded to intradermal injection of IBA in a dose-related manner over a >5-min time course and exhibited tachyphylaxis at higher concentrations (1 and 10%). Almost all WDR and low-threshold units additionally responded to the pungent agents mustard oil (allyl isothiocyanate) and/or capsaicin, prompting reclassification of the low-threshold cells as WDR. The results are discussed in terms of the functional role of WDR neurons in mediating tingle sensation.

Original languageEnglish (US)
Pages (from-to)1742-1748
Number of pages7
JournalJournal of Neurophysiology
Volume101
Issue number4
DOIs
StatePublished - Apr 2009

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ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Sawyer, C. M., Carstens, M. I., Simons, C. T., Slack, J., McCluskey, T. S., Furrer, S., & Carstens, E. (2009). Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. Journal of Neurophysiology, 101(4), 1742-1748. https://doi.org/10.1152/jn.91311.2008