Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase

Ivan N. Mefford, Alice L. Lawrenz, John K. Hsiao, Jacqueline Crawley

Research output: Contribution to journalArticlepeer-review

Abstract

LY134046, a potent, selective inhibitor of rat brain phenylethanolamine N-methyltransferase, was shown to increase activity in 18- and 19-day-old rats. The effects on day 25 were different, with LY134046 causing a decrease in activity. The effects of yohimbine, a selective antagonist of the alpha-2 adrenergic receptor, were markedly different from LY134046, causing a decrease in activity on day 19. These data suggest that epinephrine synthesis may play an inhibitory role in the regulation of activity in young rats.

Original languageEnglish (US)
Pages (from-to)240-244
Number of pages5
JournalPsychopharmacology
Volume98
Issue number2
DOIs
StatePublished - Jun 1989
Externally publishedYes

Keywords

  • Development
  • Epinephrine
  • Locomotor activity
  • Phenylethanolamine N-methyltransferase

ASJC Scopus subject areas

  • Pharmacology

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