Activated neu induces rapid tumor progression

Chantale T. Guy, Robert D. Cardiff, William J. Muller

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


Expression of the activated neu oncogene in transgenic mice has been associated with both the synchronous (single-step) and the stochastic (multistep) transformation of the mammary epithelium. To determine the basis for these conflicting observations, additional strains of transgenic mice carrying the activated neu oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer were produced. Activated neu transgene expression, as measured by in situ hybridization and ribonuclease protection assays, resulted in rapid conversion of the normal mammary epithelium to malignant phenotype in three independent strains of mice. Expression of the transgene in male mice led to epithelial hyperplasia of the epididymis and male infertility but not malignancy. These results indicate that tissue context is an important parameter in malignant progression and that expression of appropriate levels of activated neu is sufficient for rapid production of mammary tumors in transgenic mice.

Original languageEnglish (US)
Pages (from-to)7673-7678
Number of pages6
JournalJournal of Biological Chemistry
Issue number13
StatePublished - Mar 29 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Activated neu induces rapid tumor progression'. Together they form a unique fingerprint.

Cite this