Actions of GABA in developing rabbit hippocampus

an in vitro study

Alan L. Mueller, Randall M. Chesnut, Philip A Schwartzkroin

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The development of neuronal responses to γ-aminobutyric acid (GABA) was examined using intracellular recording techniques in area CA1 of rabbit hippocampal slices maintained in vitro. Micro-application of GABA (via pressure ejection) in stratum pyramidale in slices from mature rabbits (age 1 month) evoked a hyperpolarization of CA1 pyramidal neurons. The reversal potential (Erev) for this response was approximately -70 mV. In contrast, local application of GABA into stratum pyramidale in slices from immature rabbits (age 7-10 days) produced a depolarizing response with an Erev of approximately -54 mV. The relationship between these findings and the development of inhibitory synaptic activity in rabbit hippocampus is discussed.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalNeuroscience Letters
Volume39
Issue number2
DOIs
StatePublished - Aug 29 1983
Externally publishedYes

Fingerprint

gamma-Aminobutyric Acid
Hippocampus
Rabbits
Aminobutyrates
Pyramidal Cells
Pressure
In Vitro Techniques

Keywords

  • development
  • GABA
  • hippocampus
  • pressure ejection
  • rabbit

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Actions of GABA in developing rabbit hippocampus : an in vitro study. / Mueller, Alan L.; Chesnut, Randall M.; Schwartzkroin, Philip A.

In: Neuroscience Letters, Vol. 39, No. 2, 29.08.1983, p. 193-198.

Research output: Contribution to journalArticle

Mueller, Alan L. ; Chesnut, Randall M. ; Schwartzkroin, Philip A. / Actions of GABA in developing rabbit hippocampus : an in vitro study. In: Neuroscience Letters. 1983 ; Vol. 39, No. 2. pp. 193-198.
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