Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry

Gabriela Caraveo, Damian B. Van Rossum, Randen L. Patterson, Solomon H. Snyder, Stephen Desiderio

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

TFII-I is a transcription factor and a target of phosphorylation by Bruton's tyrosine kinase. In humans, deletions spanning the TFII-I locus are associated with a cognitive defect, the Williams-Beuren cognitive profile. We report an unanticipated role of TFII-I outside the nucleus as a negative regulator of agonist-induced calcium entry (ACE) that suppresses surface accumulation of TRPC3 (transient receptor potential C3) channels. Inhibition of ACE by TFII-I requires phosphotyrosine residues that engage the SH2 (Src-homology 2) domains of phospholipase C-γ (PLC-γ) and an interrupted, pleckstrin homology (PH)-like domain that binds the split PH domain of PLC-γ. Our observations suggest a model in which TFII-I suppresses ACE by competing with TRPC3 for binding to PLC-γ.

Original languageEnglish (US)
Pages (from-to)122-125
Number of pages4
JournalScience
Volume314
Issue number5796
DOIs
StatePublished - Oct 6 2006
Externally publishedYes

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Type C Phospholipases
Calcium
Transient Receptor Potential Channels
Phosphotyrosine
src Homology Domains
Transcription Factors
Phosphorylation
Pleckstrin Homology Domains

ASJC Scopus subject areas

  • General

Cite this

Caraveo, G., Van Rossum, D. B., Patterson, R. L., Snyder, S. H., & Desiderio, S. (2006). Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science, 314(5796), 122-125. https://doi.org/10.1126/science.1127815

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. / Caraveo, Gabriela; Van Rossum, Damian B.; Patterson, Randen L.; Snyder, Solomon H.; Desiderio, Stephen.

In: Science, Vol. 314, No. 5796, 06.10.2006, p. 122-125.

Research output: Contribution to journalArticle

Caraveo, G, Van Rossum, DB, Patterson, RL, Snyder, SH & Desiderio, S 2006, 'Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry', Science, vol. 314, no. 5796, pp. 122-125. https://doi.org/10.1126/science.1127815
Caraveo G, Van Rossum DB, Patterson RL, Snyder SH, Desiderio S. Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science. 2006 Oct 6;314(5796):122-125. https://doi.org/10.1126/science.1127815
Caraveo, Gabriela ; Van Rossum, Damian B. ; Patterson, Randen L. ; Snyder, Solomon H. ; Desiderio, Stephen. / Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. In: Science. 2006 ; Vol. 314, No. 5796. pp. 122-125.
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