Actin disassembly 'clock' and membrane tension determine cell shape and turning: A mathematical model

A. Mogilner, B. Rubinstein

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Motile cells regulate their shape and movements largely by remodeling the actin cytoskeleton. Principles of this regulation are becoming clear for simple-shaped steadily crawling cells, such as fish keratocytes. In particular, the shape of the leading edge and sides of the lamellipodium - cell motile appendage - is determined by graded actin distribution at the cell boundary, so that the denser actin network at the front grows, while sparser actin filaments at the sides are stalled by membrane tension. Shaping of the cell rear is less understood. Here we theoretically examine the hypothesis that the cell rear is shaped by the disassembly clock: the front-to-rear lamellipodial width is defined by the time needed for the actin-adhesion network to disassemble to the point at which the membrane tension can crush this network. We demonstrate that the theory predicts the observed cell shapes. Furthermore, turning of the cells can be explained by biases in the actin distribution. We discuss experimental implications of this hypothesis.

Original languageEnglish (US)
Article number194118
JournalJournal of Physics Condensed Matter
Volume22
Issue number19
DOIs
StatePublished - 2010

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Cell Shape
clocks
Actins
Clocks
mathematical models
Theoretical Models
Mathematical models
membranes
Membranes
cells
Fish
Adhesion
Actin Cytoskeleton
Pseudopodia
appendages
fishes
leading edges
Fishes
filaments
adhesion

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Materials Science(all)
  • Medicine(all)

Cite this

Actin disassembly 'clock' and membrane tension determine cell shape and turning : A mathematical model. / Mogilner, A.; Rubinstein, B.

In: Journal of Physics Condensed Matter, Vol. 22, No. 19, 194118, 2010.

Research output: Contribution to journalArticle

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