Acrodermatitis enteropathica and an overview of zinc metabolism

Emanual Michael Maverakis, Maxwell A Fung, Peter J. Lynch, Michelle Draznin, Daniel J. Michael, Beth Ruben, Nasim Fazel

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

Acrodermatitis enteropathica is a rare autosomal recessive disorder of zinc deficiency. The genetic defect has been mapped to 8q24 and the defective gene identified as SLC39A4, which encodes the zinc transporter Zip4. The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency.

Original languageEnglish (US)
Pages (from-to)116-124
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume56
Issue number1
DOIs
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Dermatology

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