Acoustic Signatures of Submicron Contrast Agents

Divia N. Patel, Susannah H. Bloch, Paul A. Dayton, Katherine W. Ferrara

Research output: Contribution to journalArticle

Abstract

Previous studies have revealed that hard-shelled submicron contrast agents exhibit large relative expansions and strong acoustical echoes that can be observed experimentally, and predicted by theoretical simulations. In this paper, we study harmonic imaging and pulse-pair imaging techniques designed to assist in the differentiation of these contrast agents from tissue. For harmonic imaging, we apply a high-sensitivity, narrowband strategy that differentiates the microbubble from tissue based on the generation of strong harmonic echoes. For pulse-pair imaging, we apply high spatial resolution, wideband strategies using phase inversion, which relies on the frequency differences observed in response to phase-inverted pulses, and signal subtraction, which takes advantage of the amplitude differences in response to identical pulses. The bubble-to-phantom signal amplitude ratio in the absence of motion approaches 20 dB using phase inversion and 30 dB using signal subtraction; both techniques are robust for up to 50 μm of simulated motion. With, the experience gained in these studies, we hope to advance the development of multi-pulse or shaped-pulse techniques that are optimized for specific clinical applications.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume51
Issue number3
DOIs
StatePublished - Mar 2004

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Acoustics
signatures
Imaging techniques
acoustics
pulses
Tissue
harmonics
subtraction
echoes
inversions
imaging techniques
narrowband
bubbles
spatial resolution
broadband
expansion
sensitivity
high resolution
simulation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Acoustics and Ultrasonics

Cite this

Acoustic Signatures of Submicron Contrast Agents. / Patel, Divia N.; Bloch, Susannah H.; Dayton, Paul A.; Ferrara, Katherine W.

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 51, No. 3, 03.2004, p. 293-301.

Research output: Contribution to journalArticle

Patel, Divia N. ; Bloch, Susannah H. ; Dayton, Paul A. ; Ferrara, Katherine W. / Acoustic Signatures of Submicron Contrast Agents. In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2004 ; Vol. 51, No. 3. pp. 293-301.
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