Acoustic response from adherent targeted contrast agents

Shukui Zhao, Dustin E. Kruse, Katherine W. Ferrara, Paul A. Dayton

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


In ultrasonic molecular imaging, encapsulated micron-sized gas bubbles are tethered to a blood vessel wall by targeting ligands. A challenging problem is to detect the echoes from adherent microbubbles and distinguish them from echoes from nonadherent agents and tissue. Echoes from adherent contrast agents are observed to include a high amplitude at the fundamental frequency, and significantly different spectral shape compared with free agents (p<0.0003). Mechanisms for the observed acoustical difference and potential techniques to utilize these differences for molecular imaging are proposed.

Original languageEnglish (US)
JournalJournal of the Acoustical Society of America
Issue number6
StatePublished - 2006

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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