Abstract
Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
| Pages | 521-524 |
| Number of pages | 4 |
| Volume | 1 |
| DOIs | |
| State | Published - 2006 |
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Keywords
- Radiation force
- Streaming
- Therapeutics
- Ultrasound
ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
Acoustic localization of sub-micron droplets for targeted imaging and therapy. / Dayton, Paul A.; Zhao, Shukui; Zheng, Hairong; Zutshi, Reena; Schumann, Pat; Penrose, Kim; Matsunaga, Terry O.; Ferrara, Katherine W.
Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2006. p. 521-524 4152002.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Acoustic localization of sub-micron droplets for targeted imaging and therapy
AU - Dayton, Paul A.
AU - Zhao, Shukui
AU - Zheng, Hairong
AU - Zutshi, Reena
AU - Schumann, Pat
AU - Penrose, Kim
AU - Matsunaga, Terry O.
AU - Ferrara, Katherine W.
PY - 2006
Y1 - 2006
N2 - Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.
AB - Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.
KW - Radiation force
KW - Streaming
KW - Therapeutics
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=71749104180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71749104180&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2006.146
DO - 10.1109/ULTSYM.2006.146
M3 - Conference contribution
AN - SCOPUS:71749104180
SN - 1424402018
SN - 9781424402014
VL - 1
SP - 521
EP - 524
BT - Proceedings - IEEE Ultrasonics Symposium
ER -