Acids in the brain

A factor in panic?

G. Esquivel, K. R. Schruers, Richard J Maddock, A. Colasanti, E. J. Griez

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Several methods to experimentally induce panic cause profound acid-base disturbances. Evidence suggests that CO2 inhalations, lactate infusions and, to a certain extent, voluntary hyperventilation can conceivably lead to a common scenario of brain acidosis in the face of disparate intravascular pH alterations. The importance of this event is reflected in data that support a model in which experimental panic attacks, as proxy to those occurring spontaneously, constitute a response to acute brain acidosis. Given that central CO2/H+ chemoreception is an important drive for ventilation, and many chemosensitive neurons are related to respiration and arousal, this model can explain much of the connection between panic and respiration. We propose that the shared characteristics of CO2/H + sensing neurons overlap to a point where threatening disturbances in brain pH homeostasis, such as those produced by CO2 inhalations, elicit a primal emotion that can range from breathlessness to panic.

Original languageEnglish (US)
Pages (from-to)639-647
Number of pages9
JournalJournal of Psychopharmacology
Volume24
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Panic
Acidosis
Inhalation
Acids
Brain
Respiration
Neurons
Hyperventilation
Panic Disorder
Proxy
Arousal
Dyspnea
Ventilation
Lactic Acid
Emotions
Homeostasis

Keywords

  • Acid-base imbalance
  • Anxiety
  • Carbon dioxide
  • Hyperventilation
  • Lactate
  • Panic
  • PH

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Psychiatry and Mental health

Cite this

Esquivel, G., Schruers, K. R., Maddock, R. J., Colasanti, A., & Griez, E. J. (2010). Acids in the brain: A factor in panic? Journal of Psychopharmacology, 24(5), 639-647. https://doi.org/10.1177/0269881109104847

Acids in the brain : A factor in panic? / Esquivel, G.; Schruers, K. R.; Maddock, Richard J; Colasanti, A.; Griez, E. J.

In: Journal of Psychopharmacology, Vol. 24, No. 5, 05.2010, p. 639-647.

Research output: Contribution to journalArticle

Esquivel, G, Schruers, KR, Maddock, RJ, Colasanti, A & Griez, EJ 2010, 'Acids in the brain: A factor in panic?', Journal of Psychopharmacology, vol. 24, no. 5, pp. 639-647. https://doi.org/10.1177/0269881109104847
Esquivel, G. ; Schruers, K. R. ; Maddock, Richard J ; Colasanti, A. ; Griez, E. J. / Acids in the brain : A factor in panic?. In: Journal of Psychopharmacology. 2010 ; Vol. 24, No. 5. pp. 639-647.
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