Acid-soluble precursors and derivatives of phospholipids increase after stimulation of quiescent swiss 3T3 mouse fibroblasts with serum

Craig H Warden, M. Friedkin, P. J. Geiger

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Automated phosphate analysis of acid-soluble pools of phosphate esters was employed to reveal possible biochemical changes during the transition of Swiss 3T3 mouse fibroblasts from quiescence to active replication of DNA. After 12 hours of stimulation with 10% fetal bovine serum the most notable were 3-fold increases in pools of phospholipid precursors and derivatives. These included glycerophosphocholine, glycerophosphoethanolamine, phosphocholine and phosphoethanolamine. Concurrent but less dramatic increases in pools of ATP, CTP and fructose 1,6-diphosphate were also obtained.

Original languageEnglish (US)
Pages (from-to)690-696
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume94
Issue number2
DOIs
StatePublished - May 30 1980

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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