Acid-induced mesenteric hyperemia in rats: Role of CGRP, substance P, prostaglandin, adenosine, and histamine

Felix W. Leung, Fumihiro Iwata, Kyoji Seno, Joseph Leung

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Intraduodenal acidification produces a mesenteric hyperemia that is mediated in part by mucosal capsaicin-sensitive afferent nerves and the bradykinin B2 receptor in anesthetized rats. We hypothesized that novel mechanisms mediated by substance P, adenosine, and histamine1 receptors are involved. Confirmation of a role for calcitonin gene-related peptide (CGRP) but not endogenous prostaglandin was also sought. In study 1, vehicle or antagonists (CGRP8-37, CP 96345) was administered intravenously. Capsaicin or acid was administered intraduodenally, followed by intravenous CGRP or substance P. In study 2, pretreatments included indomethacin, 8-phenyltheophylline, pyrilamine, or the respective vehicles. Acid was then administered intraduodenally. In both studies, superior mesenteric artery blood flow was monitored. In study 1, the antagonists significantly attenuated capsaicin- and acid-induced mesenteric hyperemia. In study 2, the pretreatments did not alter acid-induced hyperemia. The data confirmed the role of CGRP and indicated for the first time an involvement for substance P in acid-induced mesenteric hyperemia.

Original languageEnglish (US)
Pages (from-to)523-532
Number of pages10
JournalDigestive Diseases and Sciences
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2003

Keywords

  • Adenosine
  • CGRP
  • Mesenteric hyperemia
  • Prostaglandins
  • Substance P

ASJC Scopus subject areas

  • Gastroenterology

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