Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity

Jiyoung Lee, Andrew J. Manning, Donald Wolfgeher, Joanna Jelenska, Keri A. Cavanaugh, Huaqin Xu, Sandra M. Fernandez, Richard W Michelmore, Stephen J. Kron, Jean T. Greenberg

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Modifications of plant immune complexes by secreted pathogen effectors can trigger strong immune responses mediated by the action of nucleotide binding-leucine-rich repeat immune receptors. Although some strains of the pathogen Pseudomonas syringae harbor effectors that individually can trigger immunity, the plant's response may be suppressed by other virulence factors. This work reveals a robust strategy for immune suppression mediated by HopZ3, an effector in the YopJ family of acetyltransferases. The suppressing HopZ3 effector binds to and can acetylate multiple members of the RPM1 immune complex, as well as two P. syringae effectors that together activate the RPM1 complex. These acetylations modify serine, threonine, lysine, and/or histidine residues in the targets. Through HopZ3-mediated acetylation, it is possible that the whole effector-immune complex is inactivated, leading to increased growth of the pathogen.

Original languageEnglish (US)
Pages (from-to)1670-1682
Number of pages13
JournalCell Reports
Volume13
Issue number8
DOIs
StatePublished - Nov 24 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lee, J., Manning, A. J., Wolfgeher, D., Jelenska, J., Cavanaugh, K. A., Xu, H., Fernandez, S. M., Michelmore, R. W., Kron, S. J., & Greenberg, J. T. (2015). Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity. Cell Reports, 13(8), 1670-1682. https://doi.org/10.1016/j.celrep.2015.10.029