Abstract
Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-332 |
| Number of pages | 4 |
| Journal | Epileptic Disorders |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2009 |
| Externally published | Yes |
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Keywords
- Acetaminophen toxicity
- Carbamazepine
- Epilepsy
- Liver failure
- Renal failure
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Acetaminophen toxicity with concomitant use of carbamazepine. / Jickling, Glen; Heino, Angela; Ahmed, S. Nizam.
In: Epileptic Disorders, Vol. 11, No. 4, 12.2009, p. 329-332.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acetaminophen toxicity with concomitant use of carbamazepine
AU - Jickling, Glen
AU - Heino, Angela
AU - Ahmed, S. Nizam
PY - 2009/12
Y1 - 2009/12
N2 - Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.
AB - Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.
KW - Acetaminophen toxicity
KW - Carbamazepine
KW - Epilepsy
KW - Liver failure
KW - Renal failure
UR - http://www.scopus.com/inward/record.url?scp=76749165858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76749165858&partnerID=8YFLogxK
U2 - 10.1684/epd.2009.0274
DO - 10.1684/epd.2009.0274
M3 - Article
C2 - 19995690
AN - SCOPUS:76749165858
VL - 11
SP - 329
EP - 332
JO - Epileptic Disorders
JF - Epileptic Disorders
SN - 1294-9361
IS - 4
ER -