Acetaminophen toxicity with concomitant use of carbamazepine

Glen Jickling; Angela Heino; S. Nizam Ahmed

doi:10.1684/epd.2009.0274

Acetaminophen toxicity with concomitant use of carbamazepine

Glen Jickling, Angela Heino, S. Nizam Ahmed

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.

Original language	English (US)
Pages (from-to)	329-332
Number of pages	4
Journal	Epileptic Disorders
Volume	11
Issue number	4
DOIs	https://doi.org/10.1684/epd.2009.0274
State	Published - Dec 2009
Externally published	Yes

Keywords

Acetaminophen toxicity
Carbamazepine
Epilepsy
Liver failure
Renal failure

ASJC Scopus subject areas

Clinical Neurology
Neurology

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AU - Heino, Angela

AU - Ahmed, S. Nizam

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AB - Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.

KW - Acetaminophen toxicity

KW - Carbamazepine

KW - Epilepsy

KW - Liver failure

KW - Renal failure

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Acetaminophen toxicity with concomitant use of carbamazepine

Abstract

Keywords

ASJC Scopus subject areas

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