Acetaminophen toxicity with concomitant use of carbamazepine

Glen Jickling, Angela Heino, S. Nizam Ahmed

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalEpileptic Disorders
Volume11
Issue number4
DOIs
StatePublished - Dec 2009
Externally publishedYes

Fingerprint

Carbamazepine
Acetaminophen
Acute Liver Failure
Acute Kidney Injury
Analgesics
Seizures
Liver
Therapeutics

Keywords

  • Acetaminophen toxicity
  • Carbamazepine
  • Epilepsy
  • Liver failure
  • Renal failure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Acetaminophen toxicity with concomitant use of carbamazepine. / Jickling, Glen; Heino, Angela; Ahmed, S. Nizam.

In: Epileptic Disorders, Vol. 11, No. 4, 12.2009, p. 329-332.

Research output: Contribution to journalArticle

Jickling, Glen ; Heino, Angela ; Ahmed, S. Nizam. / Acetaminophen toxicity with concomitant use of carbamazepine. In: Epileptic Disorders. 2009 ; Vol. 11, No. 4. pp. 329-332.
@article{1715d90acb694a7494b234f97e9ea86b,
title = "Acetaminophen toxicity with concomitant use of carbamazepine",
abstract = "Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.",
keywords = "Acetaminophen toxicity, Carbamazepine, Epilepsy, Liver failure, Renal failure",
author = "Glen Jickling and Angela Heino and Ahmed, {S. Nizam}",
year = "2009",
month = "12",
doi = "10.1684/epd.2009.0274",
language = "English (US)",
volume = "11",
pages = "329--332",
journal = "Epileptic Disorders",
issn = "1294-9361",
publisher = "Springer Paris",
number = "4",

}

TY - JOUR

T1 - Acetaminophen toxicity with concomitant use of carbamazepine

AU - Jickling, Glen

AU - Heino, Angela

AU - Ahmed, S. Nizam

PY - 2009/12

Y1 - 2009/12

N2 - Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.

AB - Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.

KW - Acetaminophen toxicity

KW - Carbamazepine

KW - Epilepsy

KW - Liver failure

KW - Renal failure

UR - http://www.scopus.com/inward/record.url?scp=76749165858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749165858&partnerID=8YFLogxK

U2 - 10.1684/epd.2009.0274

DO - 10.1684/epd.2009.0274

M3 - Article

C2 - 19995690

AN - SCOPUS:76749165858

VL - 11

SP - 329

EP - 332

JO - Epileptic Disorders

JF - Epileptic Disorders

SN - 1294-9361

IS - 4

ER -