Acetaminophen and diphenhydramine as premedication for platelet transfusions: A prospective randomized double-blind placebo-controlled trial

Stephen E. Wang, Primo N Lara, Angie Lee-Ow, Jeanne Reed, Lori R. Wang, Patti Palmer, Joseph Tuscano, Carol M Richman, Laurel A Beckett, Theodore Wun

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Non-hemolytic transfusion reactions (NHTR) occur in up to 30% of patients receiving platelet transfusions. Premedication with acetaminophen and diphenhydramine is a common strategy to prevent NHTR, but its efficacy has not been studied. In this prospective trial, transfusions in patients receiving pre-storage leukocyte-reduced single-donor apheresis platelets (SDP) were randomized to premedication with either acetaminophen 650 mg PO and diphenhydramine 25 mg IV, or placebo. Fifty-one patients received 98 transfusions. Thirteen patients had 15 NHTR: 15.4% (8/52) in the treatment arm and 15.2% (7/46) in the placebo arm. Premedication prior to transfusion of pre-storage leukocyte reduced SDP does not significantly lower the incidence of NHTR as compared to placebo. Am. J. Hematol. 70:191-194, 2002.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalAmerican Journal of Hematology
Volume70
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Platelets
  • Premedication
  • Transfusion reaction

ASJC Scopus subject areas

  • Hematology

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