Accuracy of the urinalysis for urinary tract infections in febrile infants 60 days and younger

Leah S Tzimenatos, Prashant Mahajan, Peter S. Dayan, Melissa Vitale, James G. Linakis, Stephen Blumberg, Dominic Borgialli, Richard M. Ruddy, John Van Buren, Octavio Ramilo, Nathan Kuppermann

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: Reports of the test accuracy of the urinalysis for diagnosing urinary tract infections (UTIs) in young febrile infants have been variable. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, in young febrile infants. METHODS: We performed a planned secondary analysis of data from a prospective study of febrile infants .60 days old at 26 emergency departments in the Pediatric Emergency Care Applied Research Network. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, by using 2 definitions of UTI: growth of .50 000 or .10 000 colony-forming units (CFUs) per mL of a uropathogen. We defined a positive urinalysis by the presence of any leukocyte esterase, nitrite, or pyuria (>5 white blood cells per high-power field). RESULTS: Of 4147 infants analyzed, 289 (7.0%) had UTIs with colony counts .50 000 CFUs/mL, including 27 (9.3%) with bacteremia. For these UTIs, a positive urinalysis exhibited sensitivities of 0.94 (95% confidence interval [CI]: 0.91.0.97), regardless of bacteremia; 1.00 (95% CI: 0.87.1.00) with bacteremia; and 0.94 (95% CI: 0.90.0.96) without bacteremia. Specificity was 0.91 (95% CI: 0.90.0.91) in all groups. For UTIs with colony counts .10 000 CFUs/mL, the sensitivity of the urinalysis was 0.87 (95% CI: 0.83.0.90), and specificity was 0.91 (95% CI: 0.90.0.92). CONCLUSIONS: The urinalysis is highly sensitive and specific for diagnosing UTIs, especially with ≥50 000 CFUs/mL, in febrile infants ≤60 days old, and particularly for UTIs with associated bacteremia.

LanguageEnglish (US)
Article numbere20173068
JournalPediatrics
Volume141
Issue number2
DOIs
StatePublished - Feb 1 2018

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Urinalysis
Urinary Tract Infections
Bacteremia
Fever
Confidence Intervals
Stem Cells
Pyuria
Emergency Medical Services
Nitrites
Hospital Emergency Service
Leukocytes
Prospective Studies
Pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Accuracy of the urinalysis for urinary tract infections in febrile infants 60 days and younger. / Tzimenatos, Leah S; Mahajan, Prashant; Dayan, Peter S.; Vitale, Melissa; Linakis, James G.; Blumberg, Stephen; Borgialli, Dominic; Ruddy, Richard M.; Buren, John Van; Ramilo, Octavio; Kuppermann, Nathan.

In: Pediatrics, Vol. 141, No. 2, e20173068, 01.02.2018.

Research output: Contribution to journalArticle

Tzimenatos, LS, Mahajan, P, Dayan, PS, Vitale, M, Linakis, JG, Blumberg, S, Borgialli, D, Ruddy, RM, Buren, JV, Ramilo, O & Kuppermann, N 2018, 'Accuracy of the urinalysis for urinary tract infections in febrile infants 60 days and younger' Pediatrics, vol. 141, no. 2, e20173068. https://doi.org/10.1542/peds.2017-3068
Tzimenatos, Leah S ; Mahajan, Prashant ; Dayan, Peter S. ; Vitale, Melissa ; Linakis, James G. ; Blumberg, Stephen ; Borgialli, Dominic ; Ruddy, Richard M. ; Buren, John Van ; Ramilo, Octavio ; Kuppermann, Nathan. / Accuracy of the urinalysis for urinary tract infections in febrile infants 60 days and younger. In: Pediatrics. 2018 ; Vol. 141, No. 2.
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abstract = "OBJECTIVES: Reports of the test accuracy of the urinalysis for diagnosing urinary tract infections (UTIs) in young febrile infants have been variable. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, in young febrile infants. METHODS: We performed a planned secondary analysis of data from a prospective study of febrile infants .60 days old at 26 emergency departments in the Pediatric Emergency Care Applied Research Network. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, by using 2 definitions of UTI: growth of .50 000 or .10 000 colony-forming units (CFUs) per mL of a uropathogen. We defined a positive urinalysis by the presence of any leukocyte esterase, nitrite, or pyuria (>5 white blood cells per high-power field). RESULTS: Of 4147 infants analyzed, 289 (7.0{\%}) had UTIs with colony counts .50 000 CFUs/mL, including 27 (9.3{\%}) with bacteremia. For these UTIs, a positive urinalysis exhibited sensitivities of 0.94 (95{\%} confidence interval [CI]: 0.91.0.97), regardless of bacteremia; 1.00 (95{\%} CI: 0.87.1.00) with bacteremia; and 0.94 (95{\%} CI: 0.90.0.96) without bacteremia. Specificity was 0.91 (95{\%} CI: 0.90.0.91) in all groups. For UTIs with colony counts .10 000 CFUs/mL, the sensitivity of the urinalysis was 0.87 (95{\%} CI: 0.83.0.90), and specificity was 0.91 (95{\%} CI: 0.90.0.92). CONCLUSIONS: The urinalysis is highly sensitive and specific for diagnosing UTIs, especially with ≥50 000 CFUs/mL, in febrile infants ≤60 days old, and particularly for UTIs with associated bacteremia.",
author = "Tzimenatos, {Leah S} and Prashant Mahajan and Dayan, {Peter S.} and Melissa Vitale and Linakis, {James G.} and Stephen Blumberg and Dominic Borgialli and Ruddy, {Richard M.} and Buren, {John Van} and Octavio Ramilo and Nathan Kuppermann",
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AU - Tzimenatos, Leah S

AU - Mahajan, Prashant

AU - Dayan, Peter S.

AU - Vitale, Melissa

AU - Linakis, James G.

AU - Blumberg, Stephen

AU - Borgialli, Dominic

AU - Ruddy, Richard M.

AU - Buren, John Van

AU - Ramilo, Octavio

AU - Kuppermann, Nathan

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N2 - OBJECTIVES: Reports of the test accuracy of the urinalysis for diagnosing urinary tract infections (UTIs) in young febrile infants have been variable. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, in young febrile infants. METHODS: We performed a planned secondary analysis of data from a prospective study of febrile infants .60 days old at 26 emergency departments in the Pediatric Emergency Care Applied Research Network. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, by using 2 definitions of UTI: growth of .50 000 or .10 000 colony-forming units (CFUs) per mL of a uropathogen. We defined a positive urinalysis by the presence of any leukocyte esterase, nitrite, or pyuria (>5 white blood cells per high-power field). RESULTS: Of 4147 infants analyzed, 289 (7.0%) had UTIs with colony counts .50 000 CFUs/mL, including 27 (9.3%) with bacteremia. For these UTIs, a positive urinalysis exhibited sensitivities of 0.94 (95% confidence interval [CI]: 0.91.0.97), regardless of bacteremia; 1.00 (95% CI: 0.87.1.00) with bacteremia; and 0.94 (95% CI: 0.90.0.96) without bacteremia. Specificity was 0.91 (95% CI: 0.90.0.91) in all groups. For UTIs with colony counts .10 000 CFUs/mL, the sensitivity of the urinalysis was 0.87 (95% CI: 0.83.0.90), and specificity was 0.91 (95% CI: 0.90.0.92). CONCLUSIONS: The urinalysis is highly sensitive and specific for diagnosing UTIs, especially with ≥50 000 CFUs/mL, in febrile infants ≤60 days old, and particularly for UTIs with associated bacteremia.

AB - OBJECTIVES: Reports of the test accuracy of the urinalysis for diagnosing urinary tract infections (UTIs) in young febrile infants have been variable. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, in young febrile infants. METHODS: We performed a planned secondary analysis of data from a prospective study of febrile infants .60 days old at 26 emergency departments in the Pediatric Emergency Care Applied Research Network. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, by using 2 definitions of UTI: growth of .50 000 or .10 000 colony-forming units (CFUs) per mL of a uropathogen. We defined a positive urinalysis by the presence of any leukocyte esterase, nitrite, or pyuria (>5 white blood cells per high-power field). RESULTS: Of 4147 infants analyzed, 289 (7.0%) had UTIs with colony counts .50 000 CFUs/mL, including 27 (9.3%) with bacteremia. For these UTIs, a positive urinalysis exhibited sensitivities of 0.94 (95% confidence interval [CI]: 0.91.0.97), regardless of bacteremia; 1.00 (95% CI: 0.87.1.00) with bacteremia; and 0.94 (95% CI: 0.90.0.96) without bacteremia. Specificity was 0.91 (95% CI: 0.90.0.91) in all groups. For UTIs with colony counts .10 000 CFUs/mL, the sensitivity of the urinalysis was 0.87 (95% CI: 0.83.0.90), and specificity was 0.91 (95% CI: 0.90.0.92). CONCLUSIONS: The urinalysis is highly sensitive and specific for diagnosing UTIs, especially with ≥50 000 CFUs/mL, in febrile infants ≤60 days old, and particularly for UTIs with associated bacteremia.

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