Accuracy of serum β-human chorionic gonadotropin cutoff values at 42 and 49 days' gestation

Mitchell D Creinin, Leslie Meyn, Tara Klimashko

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

OBJECTIVE: The accuracy of serum β-human chorionic gonadotropin levels as cutoff values for estimating gestational age was studied. MATERIAL AND METHODS: A database was created using information from previously performed research studies, which allowed entry of women both less than and greater than 49 days' gestation, involving medical abortion. Serum β-human chorionic gonadotropin determinations and vaginal ultrasonography were performed in all studies before treatment. A total of 574 women had data available for analysis. A receiver operating characteristic curve was created to evaluate the predictive value of potential β-human chorionic gonadotropin cutoff values for 42 and 49 days' gestation. RESULTS: Appropriate serum β-human chorionic gonadotropin cutoff values for 42 and 49 days' gestation were 23,745 mlU/mL (sensitivity, 96%; specificity, 91%; positive predictive value, 68%; negative predictive value, 99%) and 71,160 mlU/mL (sensitivity, 95%; specificity, 62%; positive predictive value, 76%; negative predictive value, 91%), respectively. Under 42 days' gestation, the serum β-human chorionic gonadotropin-time relationship appears to be linear, with a greater diversity of individual values after 42 days. CONCLUSION: Serum β-human chorionic gonadotropin values can be used with reasonable accuracy to screen for a gestational age up to 49 days' gestation.

Original languageEnglish (US)
Pages (from-to)966-969
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume185
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Serum β-human chorionic gonadotropin, abortion, medical abortion, mifepristone, methotrexate, misoprostol

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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