TY - JOUR
T1 - Accuracy of pre-surgical fMRI confirmed by subsequent crossed aphasia
AU - Vitali, Paolo
AU - Dronkers, Nina
AU - Pincherle, Alexander
AU - Giovagnoli, Anna Rita
AU - Marras, Carlo
AU - D'Incerti, Ludovico
AU - Ghielmetti, Francesco
AU - Spreafico, Roberto
AU - Villani, Flavio
PY - 2011/2
Y1 - 2011/2
N2 - Atypical patterns of language activation in functional MRI (fMRI) are not unusual, particularly in patients with severe epilepsy. Still, the functional significance of these activations is under debate. We describe a case of a right-handed patient affected by drug-refractory right temporal lobe epilepsy in whom pre-surgical fMRI showed bilateral language activations, greater in the right hemisphere (RH). After surgery, a right subdural hematoma caused epileptic status and severe aphasia. This post-surgical complication of a crossed aphasia confirmed the prior fMRI findings of RH language thus stressing the value of pre-surgical fMRI evaluations, even when surgery is planned in the RH of a right-handed patient.
AB - Atypical patterns of language activation in functional MRI (fMRI) are not unusual, particularly in patients with severe epilepsy. Still, the functional significance of these activations is under debate. We describe a case of a right-handed patient affected by drug-refractory right temporal lobe epilepsy in whom pre-surgical fMRI showed bilateral language activations, greater in the right hemisphere (RH). After surgery, a right subdural hematoma caused epileptic status and severe aphasia. This post-surgical complication of a crossed aphasia confirmed the prior fMRI findings of RH language thus stressing the value of pre-surgical fMRI evaluations, even when surgery is planned in the RH of a right-handed patient.
KW - Crossed aphasia
KW - Functional MRI
KW - Hemispheric dominance
KW - Language
KW - Temporal lobe epilepsy
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U2 - 10.1007/s10072-010-0426-y
DO - 10.1007/s10072-010-0426-y
M3 - Article
C2 - 21088978
AN - SCOPUS:79551585187
VL - 32
SP - 175
EP - 180
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 1
ER -