Abstract
Atypical patterns of language activation in functional MRI (fMRI) are not unusual, particularly in patients with severe epilepsy. Still, the functional significance of these activations is under debate. We describe a case of a right-handed patient affected by drug-refractory right temporal lobe epilepsy in whom pre-surgical fMRI showed bilateral language activations, greater in the right hemisphere (RH). After surgery, a right subdural hematoma caused epileptic status and severe aphasia. This post-surgical complication of a crossed aphasia confirmed the prior fMRI findings of RH language thus stressing the value of pre-surgical fMRI evaluations, even when surgery is planned in the RH of a right-handed patient.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-180 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2011 |
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Keywords
- Crossed aphasia
- Functional MRI
- Hemispheric dominance
- Language
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Accuracy of pre-surgical fMRI confirmed by subsequent crossed aphasia. / Vitali, Paolo; Dronkers, Nina; Pincherle, Alexander; Giovagnoli, Anna Rita; Marras, Carlo; D'Incerti, Ludovico; Ghielmetti, Francesco; Spreafico, Roberto; Villani, Flavio.
In: Neurological Sciences, Vol. 32, No. 1, 02.2011, p. 175-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accuracy of pre-surgical fMRI confirmed by subsequent crossed aphasia
AU - Vitali, Paolo
AU - Dronkers, Nina
AU - Pincherle, Alexander
AU - Giovagnoli, Anna Rita
AU - Marras, Carlo
AU - D'Incerti, Ludovico
AU - Ghielmetti, Francesco
AU - Spreafico, Roberto
AU - Villani, Flavio
PY - 2011/2
Y1 - 2011/2
N2 - Atypical patterns of language activation in functional MRI (fMRI) are not unusual, particularly in patients with severe epilepsy. Still, the functional significance of these activations is under debate. We describe a case of a right-handed patient affected by drug-refractory right temporal lobe epilepsy in whom pre-surgical fMRI showed bilateral language activations, greater in the right hemisphere (RH). After surgery, a right subdural hematoma caused epileptic status and severe aphasia. This post-surgical complication of a crossed aphasia confirmed the prior fMRI findings of RH language thus stressing the value of pre-surgical fMRI evaluations, even when surgery is planned in the RH of a right-handed patient.
AB - Atypical patterns of language activation in functional MRI (fMRI) are not unusual, particularly in patients with severe epilepsy. Still, the functional significance of these activations is under debate. We describe a case of a right-handed patient affected by drug-refractory right temporal lobe epilepsy in whom pre-surgical fMRI showed bilateral language activations, greater in the right hemisphere (RH). After surgery, a right subdural hematoma caused epileptic status and severe aphasia. This post-surgical complication of a crossed aphasia confirmed the prior fMRI findings of RH language thus stressing the value of pre-surgical fMRI evaluations, even when surgery is planned in the RH of a right-handed patient.
KW - Crossed aphasia
KW - Functional MRI
KW - Hemispheric dominance
KW - Language
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=79551585187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551585187&partnerID=8YFLogxK
U2 - 10.1007/s10072-010-0426-y
DO - 10.1007/s10072-010-0426-y
M3 - Article
C2 - 21088978
AN - SCOPUS:79551585187
VL - 32
SP - 175
EP - 180
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 1
ER -