Accuracy of magnetic resonance imaging for estimating intramedullary osteosarcoma extent in pre-operative planning of canine limb-salvage procedures

Seth T. Wallack, Erik R Wisner, Jonathan A. Werner, Peter J. Walsh, Michael S Kent, Robert A. Fairley, William J. Hornof

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The objective of this work was to compare the accuracy of radiographs and magnetic resonance imaging (MRI) for estimating appendicular osteosarcoma margins. The accuracy of computed tomography (CT) and bone scintigraphy was also assessed when these studies were available. Eight dogs with appendicular osteosarcoma underwent radiographic and MRI of affected limbs. In addition, bone scintigraphy was performed in six dogs and CT examination was performed in five dogs. Two observers jointly measured tumor length on all imaging studies. Correlative gross and histologic evaluation of all affected limbs was performed to determine tumor extent as measured from the nearest articular surface. Results from imaging studies were compared to gross and microscopic morphometry findings to determine the accuracy of each modality for determining tumor boundaries. MRI images were accurate with a mean overestimation of actual tumor length of 3 ± 13%. T1-weighted non-contrast images were superior in identifying intramedullary tumor margins in most instances whereas contrast-enhanced images provided supplemental information in two dogs. Lateromedial and craniocaudal radiographs overestimated tumor length by 17 ± 28% and 4 ± 26%, respectively. Scintigraphy and CT overestimated tumor margins by 14 ± 28% and 27 ± 36%, respectively. MRI appears to be an accurate diagnostic imaging modality in determining intramedullary osteosarcoma boundaries. MRI should be considered as part of a pre-operative assessment of appendicular osteosarcoma, particularly when a limb-sparing procedure is contemplated.

Original languageEnglish (US)
Pages (from-to)432-441
Number of pages10
JournalVeterinary Radiology and Ultrasound
Volume43
Issue number5
DOIs
StatePublished - Sep 2002

Fingerprint

Limb Salvage
osteosarcoma
Osteosarcoma
limbs (animal)
magnetic resonance imaging
Canidae
planning
Magnetic Resonance Imaging
neoplasms
dogs
scintigraphy
computed tomography
Neoplasms
Radionuclide Imaging
Dogs
Extremities
Tomography
image analysis
bones
Bone and Bones

Keywords

  • Canine osteosarcoma
  • Intramedullary tumor estimation
  • MRI

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Accuracy of magnetic resonance imaging for estimating intramedullary osteosarcoma extent in pre-operative planning of canine limb-salvage procedures. / Wallack, Seth T.; Wisner, Erik R; Werner, Jonathan A.; Walsh, Peter J.; Kent, Michael S; Fairley, Robert A.; Hornof, William J.

In: Veterinary Radiology and Ultrasound, Vol. 43, No. 5, 09.2002, p. 432-441.

Research output: Contribution to journalArticle

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