Abstract
The objective of this work was to compare the accuracy of radiographs and magnetic resonance imaging (MRI) for estimating appendicular osteosarcoma margins. The accuracy of computed tomography (CT) and bone scintigraphy was also assessed when these studies were available. Eight dogs with appendicular osteosarcoma underwent radiographic and MRI of affected limbs. In addition, bone scintigraphy was performed in six dogs and CT examination was performed in five dogs. Two observers jointly measured tumor length on all imaging studies. Correlative gross and histologic evaluation of all affected limbs was performed to determine tumor extent as measured from the nearest articular surface. Results from imaging studies were compared to gross and microscopic morphometry findings to determine the accuracy of each modality for determining tumor boundaries. MRI images were accurate with a mean overestimation of actual tumor length of 3 ± 13%. T1-weighted non-contrast images were superior in identifying intramedullary tumor margins in most instances whereas contrast-enhanced images provided supplemental information in two dogs. Lateromedial and craniocaudal radiographs overestimated tumor length by 17 ± 28% and 4 ± 26%, respectively. Scintigraphy and CT overestimated tumor margins by 14 ± 28% and 27 ± 36%, respectively. MRI appears to be an accurate diagnostic imaging modality in determining intramedullary osteosarcoma boundaries. MRI should be considered as part of a pre-operative assessment of appendicular osteosarcoma, particularly when a limb-sparing procedure is contemplated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 432-441 |
| Number of pages | 10 |
| Journal | Veterinary Radiology and Ultrasound |
| Volume | 43 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2002 |
Fingerprint
Keywords
- Canine osteosarcoma
- Intramedullary tumor estimation
- MRI
ASJC Scopus subject areas
- veterinary(all)
Cite this
Accuracy of magnetic resonance imaging for estimating intramedullary osteosarcoma extent in pre-operative planning of canine limb-salvage procedures. / Wallack, Seth T.; Wisner, Erik R; Werner, Jonathan A.; Walsh, Peter J.; Kent, Michael S; Fairley, Robert A.; Hornof, William J.
In: Veterinary Radiology and Ultrasound, Vol. 43, No. 5, 09.2002, p. 432-441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accuracy of magnetic resonance imaging for estimating intramedullary osteosarcoma extent in pre-operative planning of canine limb-salvage procedures
AU - Wallack, Seth T.
AU - Wisner, Erik R
AU - Werner, Jonathan A.
AU - Walsh, Peter J.
AU - Kent, Michael S
AU - Fairley, Robert A.
AU - Hornof, William J.
PY - 2002/9
Y1 - 2002/9
N2 - The objective of this work was to compare the accuracy of radiographs and magnetic resonance imaging (MRI) for estimating appendicular osteosarcoma margins. The accuracy of computed tomography (CT) and bone scintigraphy was also assessed when these studies were available. Eight dogs with appendicular osteosarcoma underwent radiographic and MRI of affected limbs. In addition, bone scintigraphy was performed in six dogs and CT examination was performed in five dogs. Two observers jointly measured tumor length on all imaging studies. Correlative gross and histologic evaluation of all affected limbs was performed to determine tumor extent as measured from the nearest articular surface. Results from imaging studies were compared to gross and microscopic morphometry findings to determine the accuracy of each modality for determining tumor boundaries. MRI images were accurate with a mean overestimation of actual tumor length of 3 ± 13%. T1-weighted non-contrast images were superior in identifying intramedullary tumor margins in most instances whereas contrast-enhanced images provided supplemental information in two dogs. Lateromedial and craniocaudal radiographs overestimated tumor length by 17 ± 28% and 4 ± 26%, respectively. Scintigraphy and CT overestimated tumor margins by 14 ± 28% and 27 ± 36%, respectively. MRI appears to be an accurate diagnostic imaging modality in determining intramedullary osteosarcoma boundaries. MRI should be considered as part of a pre-operative assessment of appendicular osteosarcoma, particularly when a limb-sparing procedure is contemplated.
AB - The objective of this work was to compare the accuracy of radiographs and magnetic resonance imaging (MRI) for estimating appendicular osteosarcoma margins. The accuracy of computed tomography (CT) and bone scintigraphy was also assessed when these studies were available. Eight dogs with appendicular osteosarcoma underwent radiographic and MRI of affected limbs. In addition, bone scintigraphy was performed in six dogs and CT examination was performed in five dogs. Two observers jointly measured tumor length on all imaging studies. Correlative gross and histologic evaluation of all affected limbs was performed to determine tumor extent as measured from the nearest articular surface. Results from imaging studies were compared to gross and microscopic morphometry findings to determine the accuracy of each modality for determining tumor boundaries. MRI images were accurate with a mean overestimation of actual tumor length of 3 ± 13%. T1-weighted non-contrast images were superior in identifying intramedullary tumor margins in most instances whereas contrast-enhanced images provided supplemental information in two dogs. Lateromedial and craniocaudal radiographs overestimated tumor length by 17 ± 28% and 4 ± 26%, respectively. Scintigraphy and CT overestimated tumor margins by 14 ± 28% and 27 ± 36%, respectively. MRI appears to be an accurate diagnostic imaging modality in determining intramedullary osteosarcoma boundaries. MRI should be considered as part of a pre-operative assessment of appendicular osteosarcoma, particularly when a limb-sparing procedure is contemplated.
KW - Canine osteosarcoma
KW - Intramedullary tumor estimation
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=0036726203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036726203&partnerID=8YFLogxK
U2 - 10.1111/j.1740-8261.2002.tb01030.x
DO - 10.1111/j.1740-8261.2002.tb01030.x
M3 - Article
C2 - 12375777
AN - SCOPUS:0036726203
VL - 43
SP - 432
EP - 441
JO - Veterinary Radiology and Ultrasound
JF - Veterinary Radiology and Ultrasound
SN - 1058-8183
IS - 5
ER -