TY - JOUR
T1 - Accuracy of complete blood cell counts to identify febrile infants 60 days or younger with invasive bacterial infections
AU - Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network
AU - Cruz, Andrea T.
AU - Mahajan, Prashant
AU - Bonsu, Bema K.
AU - Bennett, Jonathan E.
AU - Levine, Deborah A.
AU - Alpern, Elizabeth R.
AU - Nigrovic, Lise E.
AU - Atabaki, Shireen M.
AU - Cohen, Daniel M.
AU - VanBuren, John M.
AU - Ramilo, Octavio
AU - Kuppermann, Nathan
PY - 2017/11/1
Y1 - 2017/11/1
N2 - IMPORTANCE: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. OBJECTIVE To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. DESIGN, SETTING, AND PARTICIPANTS: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up. MAIN OUTCOMES AND MEASURES: We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves. RESULTS: Of 4313 enrolled infants, 1340 (31%; 95% CI, 30% to 32%) were aged 0 to 28 days, 2412 were boys (56%), and 2471 were white (57%). Ninety-seven (2.2%; 95% CI, 1.8% to 2.7%) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/μL, 10% (95% CI, 4% to 16%) (to convert to 109 per liter, multiply by 0.001); white blood cell count 15 000/μL, 27% (95% CI, 18% to 36%); absolute neutrophil count 10 000/μL, 18% (95% CI, 10% to 25%) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/μL, 7% (95% CI, 2% to 12%) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/μL), absolute neutrophil count (4100/μL), and platelet count (362 × 103/μL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95% CI, 0.50-0.63), 0.70 (95% CI, 0.64-0.76), and 0.61 (95% CI, 0.55-0.67), respectively. CONCLUSIONS AND RELEVANCE: No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.
AB - IMPORTANCE: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. OBJECTIVE To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. DESIGN, SETTING, AND PARTICIPANTS: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up. MAIN OUTCOMES AND MEASURES: We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves. RESULTS: Of 4313 enrolled infants, 1340 (31%; 95% CI, 30% to 32%) were aged 0 to 28 days, 2412 were boys (56%), and 2471 were white (57%). Ninety-seven (2.2%; 95% CI, 1.8% to 2.7%) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/μL, 10% (95% CI, 4% to 16%) (to convert to 109 per liter, multiply by 0.001); white blood cell count 15 000/μL, 27% (95% CI, 18% to 36%); absolute neutrophil count 10 000/μL, 18% (95% CI, 10% to 25%) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/μL, 7% (95% CI, 2% to 12%) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/μL), absolute neutrophil count (4100/μL), and platelet count (362 × 103/μL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95% CI, 0.50-0.63), 0.70 (95% CI, 0.64-0.76), and 0.61 (95% CI, 0.55-0.67), respectively. CONCLUSIONS AND RELEVANCE: No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.
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U2 - 10.1001/jamapediatrics.2017.2927
DO - 10.1001/jamapediatrics.2017.2927
M3 - Article
C2 - 28892537
AN - SCOPUS:85034754926
VL - 171
JO - JAMA Pediatrics
JF - JAMA Pediatrics
SN - 2168-6203
IS - 11
M1 - e172927
ER -