Accuracy of complete blood cell counts to identify febrile infants 60 days or younger with invasive bacterial infections

Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

IMPORTANCE: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. OBJECTIVE To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. DESIGN, SETTING, AND PARTICIPANTS: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up. MAIN OUTCOMES AND MEASURES: We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves. RESULTS: Of 4313 enrolled infants, 1340 (31%; 95% CI, 30% to 32%) were aged 0 to 28 days, 2412 were boys (56%), and 2471 were white (57%). Ninety-seven (2.2%; 95% CI, 1.8% to 2.7%) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/μL, 10% (95% CI, 4% to 16%) (to convert to 109 per liter, multiply by 0.001); white blood cell count 15 000/μL, 27% (95% CI, 18% to 36%); absolute neutrophil count 10 000/μL, 18% (95% CI, 10% to 25%) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/μL, 7% (95% CI, 2% to 12%) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/μL), absolute neutrophil count (4100/μL), and platelet count (362 × 103/μL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95% CI, 0.50-0.63), 0.70 (95% CI, 0.64-0.76), and 0.61 (95% CI, 0.55-0.67), respectively. CONCLUSIONS AND RELEVANCE: No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.

Original languageEnglish (US)
Article numbere172927
JournalJAMA Pediatrics
Volume171
Issue number11
DOIs
StatePublished - Nov 1 2017

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Blood Cell Count
Bacterial Infections
Fever
Leukocyte Count
Neutrophils
Platelet Count
ROC Curve
Bacterial Meningitides
Emergency Medical Services
Bacteremia
Observational Studies
Cerebrospinal Fluid
Hospital Emergency Service
Cohort Studies
Blood Platelets
Pediatrics
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Accuracy of complete blood cell counts to identify febrile infants 60 days or younger with invasive bacterial infections. / Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network.

In: JAMA Pediatrics, Vol. 171, No. 11, e172927, 01.11.2017.

Research output: Contribution to journalArticle

Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network 2017, 'Accuracy of complete blood cell counts to identify febrile infants 60 days or younger with invasive bacterial infections', JAMA Pediatrics, vol. 171, no. 11, e172927. https://doi.org/10.1001/jamapediatrics.2017.2927
Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network. / Accuracy of complete blood cell counts to identify febrile infants 60 days or younger with invasive bacterial infections. In: JAMA Pediatrics. 2017 ; Vol. 171, No. 11.
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abstract = "IMPORTANCE: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. OBJECTIVE To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. DESIGN, SETTING, AND PARTICIPANTS: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up. MAIN OUTCOMES AND MEASURES: We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves. RESULTS: Of 4313 enrolled infants, 1340 (31{\%}; 95{\%} CI, 30{\%} to 32{\%}) were aged 0 to 28 days, 2412 were boys (56{\%}), and 2471 were white (57{\%}). Ninety-seven (2.2{\%}; 95{\%} CI, 1.8{\%} to 2.7{\%}) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/μL, 10{\%} (95{\%} CI, 4{\%} to 16{\%}) (to convert to 109 per liter, multiply by 0.001); white blood cell count 15 000/μL, 27{\%} (95{\%} CI, 18{\%} to 36{\%}); absolute neutrophil count 10 000/μL, 18{\%} (95{\%} CI, 10{\%} to 25{\%}) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/μL, 7{\%} (95{\%} CI, 2{\%} to 12{\%}) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/μL), absolute neutrophil count (4100/μL), and platelet count (362 × 103/μL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95{\%} CI, 0.50-0.63), 0.70 (95{\%} CI, 0.64-0.76), and 0.61 (95{\%} CI, 0.55-0.67), respectively. CONCLUSIONS AND RELEVANCE: No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.",
author = "{Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network} and Cruz, {Andrea T.} and Prashant Mahajan and Bonsu, {Bema K.} and Bennett, {Jonathan E.} and Levine, {Deborah A.} and Alpern, {Elizabeth R.} and Nigrovic, {Lise E.} and Atabaki, {Shireen M.} and Cohen, {Daniel M.} and VanBuren, {John M.} and Octavio Ramilo and Nathan Kuppermann",
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T1 - Accuracy of complete blood cell counts to identify febrile infants 60 days or younger with invasive bacterial infections

AU - Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network

AU - Cruz, Andrea T.

AU - Mahajan, Prashant

AU - Bonsu, Bema K.

AU - Bennett, Jonathan E.

AU - Levine, Deborah A.

AU - Alpern, Elizabeth R.

AU - Nigrovic, Lise E.

AU - Atabaki, Shireen M.

AU - Cohen, Daniel M.

AU - VanBuren, John M.

AU - Ramilo, Octavio

AU - Kuppermann, Nathan

PY - 2017/11/1

Y1 - 2017/11/1

N2 - IMPORTANCE: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. OBJECTIVE To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. DESIGN, SETTING, AND PARTICIPANTS: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up. MAIN OUTCOMES AND MEASURES: We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves. RESULTS: Of 4313 enrolled infants, 1340 (31%; 95% CI, 30% to 32%) were aged 0 to 28 days, 2412 were boys (56%), and 2471 were white (57%). Ninety-seven (2.2%; 95% CI, 1.8% to 2.7%) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/μL, 10% (95% CI, 4% to 16%) (to convert to 109 per liter, multiply by 0.001); white blood cell count 15 000/μL, 27% (95% CI, 18% to 36%); absolute neutrophil count 10 000/μL, 18% (95% CI, 10% to 25%) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/μL, 7% (95% CI, 2% to 12%) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/μL), absolute neutrophil count (4100/μL), and platelet count (362 × 103/μL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95% CI, 0.50-0.63), 0.70 (95% CI, 0.64-0.76), and 0.61 (95% CI, 0.55-0.67), respectively. CONCLUSIONS AND RELEVANCE: No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.

AB - IMPORTANCE: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. OBJECTIVE To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. DESIGN, SETTING, AND PARTICIPANTS: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up. MAIN OUTCOMES AND MEASURES: We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves. RESULTS: Of 4313 enrolled infants, 1340 (31%; 95% CI, 30% to 32%) were aged 0 to 28 days, 2412 were boys (56%), and 2471 were white (57%). Ninety-seven (2.2%; 95% CI, 1.8% to 2.7%) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/μL, 10% (95% CI, 4% to 16%) (to convert to 109 per liter, multiply by 0.001); white blood cell count 15 000/μL, 27% (95% CI, 18% to 36%); absolute neutrophil count 10 000/μL, 18% (95% CI, 10% to 25%) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/μL, 7% (95% CI, 2% to 12%) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/μL), absolute neutrophil count (4100/μL), and platelet count (362 × 103/μL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95% CI, 0.50-0.63), 0.70 (95% CI, 0.64-0.76), and 0.61 (95% CI, 0.55-0.67), respectively. CONCLUSIONS AND RELEVANCE: No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.

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