Acceptability of medical abortion with methotrexate and misoprostol

Mitchell D Creinin, Maureen Park

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A clinical trial of efficacy of methotrexate and misoprostol for abortion was performed involving 86 women requesting and abortion at < 56 days gestation. An acceptability evaluation was included in the design of the trial. Subjects were questioned before the study about their reasons for choosing a medical abortion and past experience with surgical abortion. After the study was completed, the women were questioned about their medical abortion experience. All questions were asked in an open-ended manner. Eighty-five of 86 (99%) patients completed both questionnaires. The most common reason cited as to why women chose to have a medical abortion was to avoid some aspect of the surgery (48%). Forty-one (48%) women had experienced a surgical abortion; 49% of these women chose to have a medical abortion because of a "bad" past experience related to the surgical procedure. Upon completion of the study, 67 (79%) patients stated the medical abortion was a good experience, 12 (14%) a bad experience, and 6 (7%) had a neutral response. When asked what method they would choose if they were to have another abortion, 89% would choose this method of medical abortion rather than a surgical abortion. In women who choose to participate in a clinical research trial, methotrexate and vaginal misoprostol are an acceptable and desirable method of abortion.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
Issue number1
StatePublished - 1995
Externally publishedYes


  • acceptability
  • medical abortion
  • methotrexate
  • misoprostol

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Medicine(all)


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