Accelerator mass spectrometry in biomedical research

J. S. Vogel, Ken W Turteltaub

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Biological effects occur in natural systems at chemical concentrations of parts per billion (1:109) or less. Affected biomolecules may be separable in only milligram or microgram quantities. Quantification at attomole sensitivity is needed to study these interactions. AMS measures isotope concentrations to parts per 1013-15 on milligram-sized samples and is ideal for quantifying long-lived radioisotopic labels for tracing biochemical pathways in natural systems. 14C-AMS has now been coupled to a variety of organic separation and definition technologies. Our primary research investigates pharmacokinetics and genotoxicities of toxins and drugs at very low doses. Human subjects research using AMS includes nutrition, toxicity and elemental balance studies. 3H, 41Ca and 26Al are also traced by AMS for fundamental biochemical kinetic research. Expansion of biomedical AMS awaits further development of biochemical and accelerator technologies designed specifically for these applications.

Original languageEnglish (US)
Pages (from-to)445-453
Number of pages9
JournalNuclear Inst. and Methods in Physics Research, B
Volume92
Issue number1-4
DOIs
StatePublished - Jun 3 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Instrumentation
  • Surfaces and Interfaces

Fingerprint Dive into the research topics of 'Accelerator mass spectrometry in biomedical research'. Together they form a unique fingerprint.

  • Cite this