Accelerator mass spectrometry as a bioanalytical tool for nutritional research

John S. Vogel, Ken W Turteltaub

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but is also available for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram-sized samples. Its advantages over non-isotopic and stable isotope labeling methods are reviewed and examples of analytical integrity, sensitivity, specificity, and applicability are provided.

Original languageEnglish (US)
Pages (from-to)397-410
Number of pages14
JournalAdvances in Experimental Medicine and Biology
Volume445
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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