Accelerated growth and differentiation of Fischer 344 rat keratinocytes

Thomas R Stevenson, J. W. Thornton, C. L. Marcelo

Research output: Contribution to journalArticlepeer-review


In the burned patient, rapid wound closure improves survival. A living skin equivalent (LSE) could provide early wound closure. Current cell culture techniques are slow. Hastening the culture process would permit more rapid production of an LSE, reducing burn morbidity and mortality rates. The purpose of our study is to investigate the response of neonatal Fischer 344 rat keratinocytes to low-calcium culture medium. The medium accelerates cell growth in other animal species. The growth rate and character of differentiation must be established. The Fischer 344 rat is syngeneic, thus suitable for subsequent skin graft studies using an LSE produced from pooled keratinocytes.

Original languageEnglish (US)
Pages (from-to)583
Number of pages1
JournalSurgical Forum
VolumeVOL. 36
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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