In the burned patient, rapid wound closure improves survival. A living skin equivalent (LSE) could provide early wound closure. Current cell culture techniques are slow. Hastening the culture process would permit more rapid production of an LSE, reducing burn morbidity and mortality rates. The purpose of our study is to investigate the response of neonatal Fischer 344 rat keratinocytes to low-calcium culture medium. The medium accelerates cell growth in other animal species. The growth rate and character of differentiation must be established. The Fischer 344 rat is syngeneic, thus suitable for subsequent skin graft studies using an LSE produced from pooled keratinocytes.
|Original language||English (US)|
|Number of pages||1|
|State||Published - 1985|
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