Absorption of lactoferrin-iron in suckling pigs

Gun Britt Fransson, Kerstin Thorén-Tolling, Bernt Jones, Leif Hambraeus, Bo Lönnerdal

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Lactoferrin is the major iron-binding protein in human milk, and is believed to be of importance in the mechanism of iron absorption. The absorption and retention of iron from iron-saturated bovine lactoferrin was studied in suckling pigs using 59Fe, and compared to absorption and retention of FeSO4. Lactoferrin bound iron was absorbed and incorporated into red blood cells to the same extent that sulphate iron. Net iron retention, measured by whole body counting of radioactivity one week after administration of a tracer dose, also showed a similar uptake of lactoferrin bound iron and sulphate iron. The results demonstrate that the iron-deficient suckling pig utilizes iron from lactoferrin at least as well as from an inorganic salt. Uptake data give rise to the hypothesis that the mechanisms for transfer of iron from mucosa to serosa and the incorporation of iron into red blood cells, may differ for the two compounds.

Original languageEnglish (US)
Pages (from-to)373-384
Number of pages12
JournalNutrition Research
Issue number3
StatePublished - 1983
Externally publishedYes


  • Iron
  • Iron Absorption
  • Lactoferrin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


Dive into the research topics of 'Absorption of lactoferrin-iron in suckling pigs'. Together they form a unique fingerprint.

Cite this