Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds

Anthony Cole Gallegos, Michael James Davis, Catherine N. Tchanque-Fossuo, Kaitlyn West, Angela Eisentrout-Melton, Thomas R. Peavy, Roy W. Dixon, Roma P. Patel, Sara Evona Dahle, Roslyn Rivkah Isseroff

Research output: Contribution to journalArticle

Abstract

There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment. Conclusion: The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma.

Original languageEnglish (US)
Pages (from-to)538-545
Number of pages8
JournalAdvances in Wound Care
Volume8
Issue number11
DOIs
StatePublished - Nov 1 2019

Fingerprint

Timolol
Safety
Skin
Wounds and Injuries
Ophthalmic Administration
Glaucoma
Therapeutics
Topical Administration
Respiratory Sounds
Bradycardia
Cross-Sectional Studies
Gels

Keywords

  • absorption
  • adrenergic receptor
  • catecholamine
  • chronic wounds
  • glaucoma
  • timolol

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Gallegos, A. C., Davis, M. J., Tchanque-Fossuo, C. N., West, K., Eisentrout-Melton, A., Peavy, T. R., ... Isseroff, R. R. (2019). Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds. Advances in Wound Care, 8(11), 538-545. https://doi.org/10.1089/wound.2019.0970

Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds. / Gallegos, Anthony Cole; Davis, Michael James; Tchanque-Fossuo, Catherine N.; West, Kaitlyn; Eisentrout-Melton, Angela; Peavy, Thomas R.; Dixon, Roy W.; Patel, Roma P.; Dahle, Sara Evona; Isseroff, Roslyn Rivkah.

In: Advances in Wound Care, Vol. 8, No. 11, 01.11.2019, p. 538-545.

Research output: Contribution to journalArticle

Gallegos, AC, Davis, MJ, Tchanque-Fossuo, CN, West, K, Eisentrout-Melton, A, Peavy, TR, Dixon, RW, Patel, RP, Dahle, SE & Isseroff, RR 2019, 'Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds', Advances in Wound Care, vol. 8, no. 11, pp. 538-545. https://doi.org/10.1089/wound.2019.0970
Gallegos AC, Davis MJ, Tchanque-Fossuo CN, West K, Eisentrout-Melton A, Peavy TR et al. Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds. Advances in Wound Care. 2019 Nov 1;8(11):538-545. https://doi.org/10.1089/wound.2019.0970
Gallegos, Anthony Cole ; Davis, Michael James ; Tchanque-Fossuo, Catherine N. ; West, Kaitlyn ; Eisentrout-Melton, Angela ; Peavy, Thomas R. ; Dixon, Roy W. ; Patel, Roma P. ; Dahle, Sara Evona ; Isseroff, Roslyn Rivkah. / Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds. In: Advances in Wound Care. 2019 ; Vol. 8, No. 11. pp. 538-545.
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