Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds

Anthony Cole Gallegos, Michael James Davis, Catherine N. Tchanque-Fossuo, Kaitlyn West, Angela Eisentrout-Melton, Thomas R. Peavy, Roy W. Dixon, Roma P. Patel, Sara Evona Dahle, Roslyn Rivkah Isseroff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment. Conclusion: The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma.

Original languageEnglish (US)
Pages (from-to)538-545
Number of pages8
JournalAdvances in Wound Care
Volume8
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • absorption
  • adrenergic receptor
  • catecholamine
  • chronic wounds
  • glaucoma
  • timolol

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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