Abstract
There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment. Conclusion: The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma.
Original language | English (US) |
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Pages (from-to) | 538-545 |
Number of pages | 8 |
Journal | Advances in Wound Care |
Volume | 8 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2019 |
Externally published | Yes |
Keywords
- absorption
- adrenergic receptor
- catecholamine
- chronic wounds
- glaucoma
- timolol
ASJC Scopus subject areas
- Emergency Medicine
- Critical Care and Intensive Care Medicine