Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds

Anthony Cole Gallegos; Michael James Davis; Catherine N. Tchanque-Fossuo; Kaitlyn West; Angela Eisentrout-Melton; Thomas R. Peavy; Roy W. Dixon; Roma P. Patel; Sara Evona Dahle; Roslyn Rivkah Isseroff

doi:10.1089/wound.2019.0970

Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds

Anthony Cole Gallegos, Michael James Davis, Catherine N. Tchanque-Fossuo, Kaitlyn West, Angela Eisentrout-Melton, Thomas R. Peavy, Roy W. Dixon, Roma P. Patel, Sara Evona Dahle, Roslyn Rivkah Isseroff

Dermatology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment. Conclusion: The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma.

Original language	English (US)
Pages (from-to)	538-545
Number of pages	8
Journal	Advances in Wound Care
Volume	8
Issue number	11
DOIs	https://doi.org/10.1089/wound.2019.0970
State	Published - Nov 1 2019

Keywords

absorption
adrenergic receptor
catecholamine
chronic wounds
glaucoma
timolol

ASJC Scopus subject areas

Emergency Medicine
Critical Care and Intensive Care Medicine

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10.1089/wound.2019.0970

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Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds. / Gallegos, Anthony Cole; Davis, Michael James; Tchanque-Fossuo, Catherine N.; West, Kaitlyn; Eisentrout-Melton, Angela; Peavy, Thomas R.; Dixon, Roy W.; Patel, Roma P.; Dahle, Sara Evona; Isseroff, Roslyn Rivkah.

In: Advances in Wound Care, Vol. 8, No. 11, 01.11.2019, p. 538-545.

Research output: Contribution to journal › Article › peer-review

Gallegos, Anthony Cole ; Davis, Michael James ; Tchanque-Fossuo, Catherine N. ; West, Kaitlyn ; Eisentrout-Melton, Angela ; Peavy, Thomas R. ; Dixon, Roy W. ; Patel, Roma P. ; Dahle, Sara Evona ; Isseroff, Roslyn Rivkah. / Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds. In: Advances in Wound Care. 2019 ; Vol. 8, No. 11. pp. 538-545.

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abstract = "There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment. Conclusion: The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma.",

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Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds

Abstract

Keywords

ASJC Scopus subject areas

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