Absolute eigenvalue diffusion tensor analysis for human brain maturation

Yuji Suzuki, Hitoshi Matsuzawa, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

The absolute eigenvalues of the diffusion tensor of white matter in sixteen normal subjects in two groups representing the early developmental stage (ages 1-10 years, n = 8) and young adult stage (ages 18-34 years, n = 8) were assessed using a high-field (3.0 T) magnetic resonance (MR) system. All three eigenvalues, including the largest eigenvalue, decreased significantly with brain maturation. The rate of the decline in the two small eigenvalues was, however, much higher than that of the largest eigenvalue, resulting in an actual increase in fractional anisotropy, a commonly measured relative index. The data demonstrate that an increase in anisotropy associated with brain maturation represents a significant decline in the small eigenvalue components, rather than an increase in the largest eigenvalue. The observed pattern of eigenvalue changes is best explained by the simultaneous occurrence of two of several independent phenomena within the axonal microenvironment during the myelination process, namely, (1) decline in unrestricted water content in extra-axonal space, and (2) increase in apparent diffusivity within the axon.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalNMR in Biomedicine
Volume16
Issue number5
DOIs
StatePublished - Aug 2003

Keywords

  • Axon
  • Brain maturation
  • Diffusion tensor analysis
  • Eigenvalue
  • Myelination

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

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