Absence of Myelofibrosis in Dogs with Myelosuppression Induced by Ehrlichia canis Infection

M. E. Mylonakis, M. J. Day, V. Siarkou, William Vernau, A. F. Koutinas

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Bone marrow (BM) pathology was assessed in 10 dogs with Ehrlichia canis-induced aplastic pancytopenia. BM core biopsy sections were stained with haematoxylin and eosin and with haematoxylin/van Gieson and Gordon and Sweets' reticulin stain for the detection of collagen and reticulin fibres, respectively. Iron stores were assessed by Perls' Prussian blue staining. There was no significant deposition of collagen or reticulin in any sample, but in seven dogs the BM was depleted of haemosiderin. These findings suggest that myelofibrosis does not play a significant role in the development of BM failure in canine monocytic ehrlichiosis and that iron deficiency may exacerbate the anaemia in the myelosuppressive phase of the disease.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalJournal of Comparative Pathology
Volume142
Issue number4
DOIs
StatePublished - May 2010

Fingerprint

Ehrlichia canis
Primary Myelofibrosis
reticulin
Reticulin
bone marrow
Bone Marrow
Dogs
dogs
Hematoxylin
Infection
infection
collagen
Collagen
Iron
Ehrlichiosis
hemosiderin
iron
Hemosiderin
ehrlichiosis
Pancytopenia

Keywords

  • Aplastic pancytopenia
  • Dog
  • Ehrlichia canis
  • Myelofibrosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Absence of Myelofibrosis in Dogs with Myelosuppression Induced by Ehrlichia canis Infection. / Mylonakis, M. E.; Day, M. J.; Siarkou, V.; Vernau, William; Koutinas, A. F.

In: Journal of Comparative Pathology, Vol. 142, No. 4, 05.2010, p. 328-331.

Research output: Contribution to journalArticle

Mylonakis, M. E. ; Day, M. J. ; Siarkou, V. ; Vernau, William ; Koutinas, A. F. / Absence of Myelofibrosis in Dogs with Myelosuppression Induced by Ehrlichia canis Infection. In: Journal of Comparative Pathology. 2010 ; Vol. 142, No. 4. pp. 328-331.
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