Absence of galectin-3 does not affect the development of experimental tongue carcinomas in mice

Paulo Rogério de Faria, Roger Chammas, Thaissa Lopes de Melo, Daniel K. Hsu, Fu-Tong Liu, Suely Nonogaki, Sérgio Vitorino Cardoso, Adriano Mota Loyola

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. Aims: To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral carcinogenesis. Methods: Galectin-3-deficient (gal3-/-) and wild-type (gal3+/+) mice were challenged with 4-nitroquinoline-1-oxide in drinking water for 16weeks and killed at different times. Tongues were removed and the number of dysplasias and carcinomas was counted. An immunohistochemical study for galectin-3 was performed only in the tongue from gal3+/+ mice. Results: In both groups, a reduction of dysplasias and an increase of carcinomas from week 16 to week 32 (p > 0.05) were observed. A predominance of high cytoplasmic and nuclear galectin-3 expression was observed in carcinomas (64.7%) and dysplasias (55.5%), respectively (p > 0.05). The perilesional areas always presented a statistical cytoplasmic and nuclear galectin-3 overexpression. Conclusions: Absence of galectin-3 did not directly affect the process of carcinogenesis and a cytoplasm shift of galectin-3 seems to be associated with development of tongue carcinomas.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalExperimental and Molecular Pathology
Volume90
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • Galectin-3
  • Mice
  • Oral carcinogenesis
  • Oral squamous cell carcinoma
  • Premalignant lesions
  • Tongue

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

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    de Faria, P. R., Chammas, R., de Melo, T. L., Hsu, D. K., Liu, F-T., Nonogaki, S., Cardoso, S. V., & Loyola, A. M. (2011). Absence of galectin-3 does not affect the development of experimental tongue carcinomas in mice. Experimental and Molecular Pathology, 90(2), 189-193. https://doi.org/10.1016/j.yexmp.2010.12.007