Monoclonal antibodies which recognize human suppressor T cells (OKT8) have been reported by Oger and co-workers to bind to cultured sheep oligodendrocytes1. These authors speculated that an immune response directed at determinants shared by suppressor lymphocytes and oligodendrocytes could explain the decrease in both circulating blood suppressor T cells 2,3 and oligodendrocytes4 in patients with multiple sclerosis. In view of the vital issue of potential cross-reactivity between oligodendrocytes and lymphocytes, we studied the binding of viable cultured calf5, rat6 and human7 oligodendrocytes using monoclonal antibodies to human T cells and monocytes8. We report here that we were unable to confirm the presence of shared determinants among oligodendrocytes and any leukocytes, including human T cells or monocytes. As the reported observations of lymphocyte-oligodendrocyte shared determinants could not be identified in three other species, including man, we found no evidence to support the hypothesis that such shared determinants are of importance in the pathogenesis of multiple sclerosis.
ASJC Scopus subject areas