Abstract
Monoclonal antibodies which recognize human suppressor T cells (OKT8) have been reported by Oger and co-workers to bind to cultured sheep oligodendrocytes1. These authors speculated that an immune response directed at determinants shared by suppressor lymphocytes and oligodendrocytes could explain the decrease in both circulating blood suppressor T cells 2,3 and oligodendrocytes4 in patients with multiple sclerosis. In view of the vital issue of potential cross-reactivity between oligodendrocytes and lymphocytes, we studied the binding of viable cultured calf5, rat6 and human7 oligodendrocytes using monoclonal antibodies to human T cells and monocytes8. We report here that we were unable to confirm the presence of shared determinants among oligodendrocytes and any leukocytes, including human T cells or monocytes. As the reported observations of lymphocyte-oligodendrocyte shared determinants could not be identified in three other species, including man, we found no evidence to support the hypothesis that such shared determinants are of importance in the pathogenesis of multiple sclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 152-154 |
| Number of pages | 3 |
| Journal | Nature |
| Volume | 301 |
| Issue number | 5896 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Absence of expression of OKT8 antigen on cultured human, calf and rat oligodendrocytes. / Hirayama, Mikio; Lisak, Robert P.; Kim, Seung U.; Pleasure, David E; Silberberg, Donald H.
In: Nature, Vol. 301, No. 5896, 1983, p. 152-154.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Absence of expression of OKT8 antigen on cultured human, calf and rat oligodendrocytes
AU - Hirayama, Mikio
AU - Lisak, Robert P.
AU - Kim, Seung U.
AU - Pleasure, David E
AU - Silberberg, Donald H.
PY - 1983
Y1 - 1983
N2 - Monoclonal antibodies which recognize human suppressor T cells (OKT8) have been reported by Oger and co-workers to bind to cultured sheep oligodendrocytes1. These authors speculated that an immune response directed at determinants shared by suppressor lymphocytes and oligodendrocytes could explain the decrease in both circulating blood suppressor T cells 2,3 and oligodendrocytes4 in patients with multiple sclerosis. In view of the vital issue of potential cross-reactivity between oligodendrocytes and lymphocytes, we studied the binding of viable cultured calf5, rat6 and human7 oligodendrocytes using monoclonal antibodies to human T cells and monocytes8. We report here that we were unable to confirm the presence of shared determinants among oligodendrocytes and any leukocytes, including human T cells or monocytes. As the reported observations of lymphocyte-oligodendrocyte shared determinants could not be identified in three other species, including man, we found no evidence to support the hypothesis that such shared determinants are of importance in the pathogenesis of multiple sclerosis.
AB - Monoclonal antibodies which recognize human suppressor T cells (OKT8) have been reported by Oger and co-workers to bind to cultured sheep oligodendrocytes1. These authors speculated that an immune response directed at determinants shared by suppressor lymphocytes and oligodendrocytes could explain the decrease in both circulating blood suppressor T cells 2,3 and oligodendrocytes4 in patients with multiple sclerosis. In view of the vital issue of potential cross-reactivity between oligodendrocytes and lymphocytes, we studied the binding of viable cultured calf5, rat6 and human7 oligodendrocytes using monoclonal antibodies to human T cells and monocytes8. We report here that we were unable to confirm the presence of shared determinants among oligodendrocytes and any leukocytes, including human T cells or monocytes. As the reported observations of lymphocyte-oligodendrocyte shared determinants could not be identified in three other species, including man, we found no evidence to support the hypothesis that such shared determinants are of importance in the pathogenesis of multiple sclerosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020656678&partnerID=8YFLogxK
U2 - 10.1038/301152a0
DO - 10.1038/301152a0
M3 - Article
C2 - 6185848
AN - SCOPUS:0020656678
VL - 301
SP - 152
EP - 154
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5896
ER -