Absence of Equid Herpesvirus-1 Reactivation and Viremia in Hospitalized Critically Ill Horses

E. A. Carr, H. Schott, Nicola Pusterla

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Equid herpesvirus-1 (EHV-1) reactivation and shedding can occur in latently infected, asymptomatic animals. Risk factors for reactivation include stress and illness. The risk of asymptomatic shedding in hospitalized, critically ill horses with acute abdominal disease is unknown. This information is important to assess the need for additional biosecurity protocols to prevent spread of EHV-1 in hospitalized critically ill horses with acute abdominal disorders. Objectives: To determine the frequency of reactivation and nasal shedding of EHV-1 in hospitalized critically ill horses. Animals: One hundred twenty-four client-owned horses admitted to the Veterinary Teaching Hospital with acute abdominal disorders were included in the study. Methods: Cross-sectional study examining the risk of reactivation of EHV-1 in horses admitted with acute, severe, gastrointestinal disease. Whole blood and nasal secretions were collected throughout hospitalization. In addition, mandibular lymph nodes were collected from 9 study horses and 26 other Michigan horses. All samples were tested for the presence of EHV-1 nucleic acid by real-time PCR assays targeting the glycoprotein B gene and the polymerase (ORF 30) gene. Results: One hundred and twenty-four horses met the inclusion criteria. None of the samples were positive for EHV-1 DNA. Conclusion and Clinical Importance: These results suggest that nasal shedding and viremia of EHV-1 in hospitalized critically ill horses with acute abdominal disorder is extremely rare. Implementation of additional biosecurity protocols to limit aerosol spread of EHV-1 among horses with acute abdominal disease and other hospitalized horses is not necessary.

Original languageEnglish (US)
Pages (from-to)1190-1193
Number of pages4
JournalJournal of Veterinary Internal Medicine
Volume25
Issue number5
DOIs
StatePublished - Sep 2011

Fingerprint

Equid Herpesvirus 1
Equid herpesvirus 1
Viremia
viremia
Critical Illness
Horses
horses
Nose
biosecurity
Acute Disease
Animal Hospitals
Gastrointestinal Diseases
aerosols
digestive system diseases
Aerosols
cross-sectional studies
Teaching Hospitals
Nucleic Acids
nucleic acids
Open Reading Frames

Keywords

  • Gastrointestinal disease
  • Horse
  • Nasal shedding
  • Reactivation

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Absence of Equid Herpesvirus-1 Reactivation and Viremia in Hospitalized Critically Ill Horses. / Carr, E. A.; Schott, H.; Pusterla, Nicola.

In: Journal of Veterinary Internal Medicine, Vol. 25, No. 5, 09.2011, p. 1190-1193.

Research output: Contribution to journalArticle

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