Absence of detectable pharmacological effects after oral administration of isoxsuprine

J. D. Harkins, G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, T. Tobin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalEquine Veterinary Journal
Volume30
Issue number4
StatePublished - 1998

Keywords

  • Behaviour chamber
  • Cutaneous blood flow
  • Heart rate
  • Horse
  • Isoxsuprine
  • Muscle tone
  • Pharmacological effect
  • Sweat production
  • Temperature

ASJC Scopus subject areas

  • veterinary(all)

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