Absence of detectable pharmacological effects after oral administration of isoxsuprine

J. D. Harkins, G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, T. Tobin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalEquine Veterinary Journal
Volume30
Issue number4
StatePublished - 1998

Fingerprint

isoxsuprine
Isoxsuprine
oral administration
Oral Administration
Pharmacology
Horses
navicular disease
horses
sweat
vasodilator agents
vascular diseases
skin temperature
duration
Veterinary Medicine
Skin Temperature
Sweat
limbs (animal)
Vasodilator Agents
Vascular Diseases
blood flow

Keywords

  • Behaviour chamber
  • Cutaneous blood flow
  • Heart rate
  • Horse
  • Isoxsuprine
  • Muscle tone
  • Pharmacological effect
  • Sweat production
  • Temperature

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Harkins, J. D., Mundy, G. D., Stanley, S., Woods, W. E., Sams, R. A., Richardson, D. R., ... Tobin, T. (1998). Absence of detectable pharmacological effects after oral administration of isoxsuprine. Equine Veterinary Journal, 30(4), 294-299.

Absence of detectable pharmacological effects after oral administration of isoxsuprine. / Harkins, J. D.; Mundy, G. D.; Stanley, S.; Woods, W. E.; Sams, R. A.; Richardson, D. R.; Grambow, S. C.; Tobin, T.

In: Equine Veterinary Journal, Vol. 30, No. 4, 1998, p. 294-299.

Research output: Contribution to journalArticle

Harkins, JD, Mundy, GD, Stanley, S, Woods, WE, Sams, RA, Richardson, DR, Grambow, SC & Tobin, T 1998, 'Absence of detectable pharmacological effects after oral administration of isoxsuprine', Equine Veterinary Journal, vol. 30, no. 4, pp. 294-299.
Harkins JD, Mundy GD, Stanley S, Woods WE, Sams RA, Richardson DR et al. Absence of detectable pharmacological effects after oral administration of isoxsuprine. Equine Veterinary Journal. 1998;30(4):294-299.
Harkins, J. D. ; Mundy, G. D. ; Stanley, S. ; Woods, W. E. ; Sams, R. A. ; Richardson, D. R. ; Grambow, S. C. ; Tobin, T. / Absence of detectable pharmacological effects after oral administration of isoxsuprine. In: Equine Veterinary Journal. 1998 ; Vol. 30, No. 4. pp. 294-299.
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