Abortive apoptosis as an initiator of chromosomal translocations

N. N. Khodarev, I. A. Sokolova, Andrew T M Vaughan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Apoptosis is a well-recognized regulator of a cell populations size and structure. Irreversible stages of apoptosis lead to activation of different enzymatic cascades, changes in cell morphology and DNA fragmentation. However, little is known about nuclear events which accompany the initial stages of apoptosis. These events are connected with introduction of limited amounts of double strand breaks into genomic DNA, some of which may be subsequently rejoined. We hypothesize here that the initial stages of apoptotic DNA fragmentation may be reversible and connected with the initiation of recombinational events and certain chromosomal translocations. The factors influencing apoptosis reversibility and cell survival after delivery of apoptotic stimuli may provide new insights into mechanisms of lymphocyte development and tumorigenesis.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalMedical Hypotheses
Volume52
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

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