Abnormalities in sex hormones are a risk factor for premature manifestation of coronary artery disease in South African Indian men

M. Sewdarsen, S. Vythilingum, I. Jalal, R. K. Desai, P. Becker

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The relation between sex hormone levels and myocardial infarction was studied in a case-control study among 117 Indian men with myocardial infarction aged 30-60 years and in 107 healthy Indian male controls. The patients and controls were further divided into subsets defined by age in decades. In the total patient population, testosterone concentration was significantly lower than in the controls (P < 0.01), whilst oestradiol (P < 0.0005) and the oestradiol to testosterone ratio (P < 0.0005) were significantly higher. Multivariate stepwise logistic regression analyses demonstrated that free testosterone index, the free oestradiol index, and the oestradiol to testosterone ratio were significantly associated with myocardial infarction, and that this association was independent of age, body mass index, smoking and serum lipids. Further analyses according to age subsets revealed that compared to respective control groups, patients in the 4th decade had both significant hypotestosteronaemia and hyperoestrogenaemia, whereas in patients of the 5th decade significant differences in total and in the calculated free oestradiol index were noted, and in the 6th decade a significant difference was detected only in the free oestradiol index. Hence, we conclude that aberrations in endogenous sex hormones are significantly associated with myocardial infarction, and that this association appears to be strongest in young men and diminishes with age, suggesting that these disturbances in sex hormones may be associated with premature manifestation of coronary artery disease.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalAtherosclerosis
Volume83
Issue number2-3
DOIs
StatePublished - 1990
Externally publishedYes

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Gonadal Steroid Hormones
Coronary Artery Disease
Estradiol
Testosterone
Myocardial Infarction
Case-Control Studies
Body Mass Index
Logistic Models
Smoking
Regression Analysis
Lipids
Control Groups
Serum
Population

Keywords

  • Myocardial infarction
  • Risk factors
  • Sex hormones

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Abnormalities in sex hormones are a risk factor for premature manifestation of coronary artery disease in South African Indian men. / Sewdarsen, M.; Vythilingum, S.; Jalal, I.; Desai, R. K.; Becker, P.

In: Atherosclerosis, Vol. 83, No. 2-3, 1990, p. 111-117.

Research output: Contribution to journalArticle

Sewdarsen, M. ; Vythilingum, S. ; Jalal, I. ; Desai, R. K. ; Becker, P. / Abnormalities in sex hormones are a risk factor for premature manifestation of coronary artery disease in South African Indian men. In: Atherosclerosis. 1990 ; Vol. 83, No. 2-3. pp. 111-117.
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