Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia

James A. Waltz, Julie B Schweitzer, Thomas J. Ross, Pradeep K. Kurup, Betty J. Salmeron, Emma J. Rose, James M. Gold, Elliot A. Stein

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Psychosis has been associated with aberrant brain activity concurrent with both the anticipation and integration of monetary outcomes. The extent to which abnormal reward-related neural signals can be observed in chronic, medicated patients with schizophrenia (SZ), however, is not clear. In an fMRI study involving 17 chronic outpatients with SZ and 17 matched controls, we used a monetary incentive delay (MID) task, in which different-colored shapes predicted gains, losses, or neutral outcomes. Subjects needed to respond to a target within a time window in order to receive the indicated gain or avoid the indicated loss. Group differences in blood-oxygen-level-dependent responses to cues and outcomes were assessed through voxel-wise whole-brain analyses and regions-of-interest analyses in the neostriatum and prefrontal cortex (PFC). Significant group by outcome valence interactions were observed in the medial and lateral PFC, lateral temporal cortex, and amygdalae, such that controls, but not patients, showed greater activation for gains, relative to losses. In the striatum, neural activity was modulated by outcome magnitude in both groups. Additionally, we found that ratings of negative symptoms in patients correlated with sensitivity to obtained losses in medial PFC, obtained gains in lateral PFC, and anticipated gains in left ventral striatum. Sensitivity to obtained gains in lateral PFC also correlated with positive symptom scores in patients. Our findings of systematic relationships between clinical symptoms and neural responses to stimuli associated with rewards and punishments offer promise that reward-related neural responses may provide sensitive probes of the effectiveness of treatments for negative symptoms.

Original languageEnglish (US)
Pages (from-to)2427-2439
Number of pages13
JournalNeuropsychopharmacology
Volume35
Issue number12
DOIs
StatePublished - Nov 2010

Fingerprint

Basal Ganglia
Prefrontal Cortex
Schizophrenia
Reward
Neostriatum
Punishment
Brain
Temporal Lobe
Amygdala
Psychotic Disorders
Cues
Motivation
Outpatients
Magnetic Resonance Imaging
Oxygen

Keywords

  • basal ganglia
  • dopamine
  • reinforcement
  • schizophrenia
  • ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Waltz, J. A., Schweitzer, J. B., Ross, T. J., Kurup, P. K., Salmeron, B. J., Rose, E. J., ... Stein, E. A. (2010). Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia. Neuropsychopharmacology, 35(12), 2427-2439. https://doi.org/10.1038/npp.2010.126

Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia. / Waltz, James A.; Schweitzer, Julie B; Ross, Thomas J.; Kurup, Pradeep K.; Salmeron, Betty J.; Rose, Emma J.; Gold, James M.; Stein, Elliot A.

In: Neuropsychopharmacology, Vol. 35, No. 12, 11.2010, p. 2427-2439.

Research output: Contribution to journalArticle

Waltz, JA, Schweitzer, JB, Ross, TJ, Kurup, PK, Salmeron, BJ, Rose, EJ, Gold, JM & Stein, EA 2010, 'Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia', Neuropsychopharmacology, vol. 35, no. 12, pp. 2427-2439. https://doi.org/10.1038/npp.2010.126
Waltz, James A. ; Schweitzer, Julie B ; Ross, Thomas J. ; Kurup, Pradeep K. ; Salmeron, Betty J. ; Rose, Emma J. ; Gold, James M. ; Stein, Elliot A. / Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia. In: Neuropsychopharmacology. 2010 ; Vol. 35, No. 12. pp. 2427-2439.
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