Abnormal premovement brain potentials in schizophrenia

Jaswinder Singh, Robert T. Knight, N. Rosenlicht, Joan M. Kotun, D. J. Beckley, David L Woods

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We assessed scalp-recorded movement related potentials (MRPs) generated prior to voluntary movements in chronic, medicated schizophrenics (n = 9) and age matched normal controls (n = 9). MRPs were recorded in a self-paced button press task in which subjects pressed a button with either their right, left or both thumbs (experimental condition I, II and III respectively). Controls generated a slowly rising readiness potential (RP) at about 1000 ms, a negative shift (NS') at about 450 ms and a motor potential (MP) at about 100 ms prior to movement. The initial MRP components (RP and NS') were reduced in schizophrenics indicating an impairment of the voluntary preparatory process in schizophrenia. Results of the present study indicate a similarity of MRP findings in schizophrenics and reported MRPs (Singh and Knight, 1990) in patients with unilateral lesions of the dorsolateral prefrontal cortex. These findings provide further support for frontal lobe dysfunction in schizophrenia.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalSchizophrenia Research
Volume8
Issue number1
DOIs
StatePublished - 1992

Keywords

  • (Schizophrenia)
  • Frontal lobes
  • Movement-related potentials
  • Readiness potential
  • Schizophrenia
  • Voluntary movements

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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    Singh, J., Knight, R. T., Rosenlicht, N., Kotun, J. M., Beckley, D. J., & Woods, D. L. (1992). Abnormal premovement brain potentials in schizophrenia. Schizophrenia Research, 8(1), 31-41. https://doi.org/10.1016/0920-9964(92)90058-D