Abnormal plasma neuroactive progestagen derivatives in ill, neonatal foals presented to the neonatal intensive care unit

Monica R Aleman, K. J. Pickles, Alan J Conley, Scott D Stanley, E. Haggett, B. Toth, John E Madigan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Reasons for performing the study: Increased levels of pregnanes have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have depressive effects in the central nervous system leading to behavioural abnormalities and altered states of consciousness in affected foals. Objectives: The aim of this study was to determine the pregnane profile of foals with NMS and compare it with that of healthy controls and sick, non-NMS foals. Study design: Prospective-clinical study. Methods: Thirty-two foals with a clinical diagnosis of NMS, 12 foals with other neonatal disorders and 10 healthy control foals were selected for the study. Heparinised blood samples were collected from each group of foals and pregnane and androgen concentrations determined using liquid chromatography mass spectrometry at 0, 24 and 48h of age. Results: Healthy foals showed a significant decrease in pregnane concentrations over the first 48h of life (P<0.01). Foals with NMS and sick, non-NMS foals had significantly increased progesterone, pregnenolone, androstenedione, dehydroepiandrosterone and epitestosterone concentrations compared with healthy foals (P<0.05). Progesterone and pregnenolone concentrations of sick, non-NMS foals decreased significantly over 48h (P<0.05), whereas concentrations in NMS foals remained increased. Conclusions and potential relevance: Pregnane concentrations of ill, neonatal foals remain increased following birth, reflecting a delayed, or interrupted, transition from intra- to extra-uterine life. Serial progesterone and pregnenolone measurement may be useful in aiding diagnosis of NMS.

Original languageEnglish (US)
Pages (from-to)661-665
Number of pages5
JournalEquine Veterinary Journal
Volume45
Issue number6
DOIs
StatePublished - Nov 2013

Fingerprint

progestational hormones
Neonatal Intensive Care Units
Progestins
foals
Pregnanes
Pregnenolone
Progesterone
pregnenolone
Epitestosterone
progesterone
Dehydroepiandrosterone
Androstenedione
Blood-Brain Barrier
Consciousness
Liquid Chromatography
Androgens
Mass Spectrometry
prasterone
Central Nervous System
androstenedione

Keywords

  • Foals
  • Horse
  • Hypoxia
  • Neurosteroids
  • Pregnanes
  • Progestagens

ASJC Scopus subject areas

  • Equine

Cite this

@article{ef85311082d247819cc0969f3d3bd5c3,
title = "Abnormal plasma neuroactive progestagen derivatives in ill, neonatal foals presented to the neonatal intensive care unit",
abstract = "Reasons for performing the study: Increased levels of pregnanes have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have depressive effects in the central nervous system leading to behavioural abnormalities and altered states of consciousness in affected foals. Objectives: The aim of this study was to determine the pregnane profile of foals with NMS and compare it with that of healthy controls and sick, non-NMS foals. Study design: Prospective-clinical study. Methods: Thirty-two foals with a clinical diagnosis of NMS, 12 foals with other neonatal disorders and 10 healthy control foals were selected for the study. Heparinised blood samples were collected from each group of foals and pregnane and androgen concentrations determined using liquid chromatography mass spectrometry at 0, 24 and 48h of age. Results: Healthy foals showed a significant decrease in pregnane concentrations over the first 48h of life (P<0.01). Foals with NMS and sick, non-NMS foals had significantly increased progesterone, pregnenolone, androstenedione, dehydroepiandrosterone and epitestosterone concentrations compared with healthy foals (P<0.05). Progesterone and pregnenolone concentrations of sick, non-NMS foals decreased significantly over 48h (P<0.05), whereas concentrations in NMS foals remained increased. Conclusions and potential relevance: Pregnane concentrations of ill, neonatal foals remain increased following birth, reflecting a delayed, or interrupted, transition from intra- to extra-uterine life. Serial progesterone and pregnenolone measurement may be useful in aiding diagnosis of NMS.",
keywords = "Foals, Horse, Hypoxia, Neurosteroids, Pregnanes, Progestagens",
author = "Aleman, {Monica R} and Pickles, {K. J.} and Conley, {Alan J} and Stanley, {Scott D} and E. Haggett and B. Toth and Madigan, {John E}",
year = "2013",
month = "11",
doi = "10.1111/evj.12065",
language = "English (US)",
volume = "45",
pages = "661--665",
journal = "Equine veterinary journal. Supplement",
issn = "2042-3306",
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TY - JOUR

T1 - Abnormal plasma neuroactive progestagen derivatives in ill, neonatal foals presented to the neonatal intensive care unit

AU - Aleman, Monica R

AU - Pickles, K. J.

AU - Conley, Alan J

AU - Stanley, Scott D

AU - Haggett, E.

AU - Toth, B.

AU - Madigan, John E

PY - 2013/11

Y1 - 2013/11

N2 - Reasons for performing the study: Increased levels of pregnanes have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have depressive effects in the central nervous system leading to behavioural abnormalities and altered states of consciousness in affected foals. Objectives: The aim of this study was to determine the pregnane profile of foals with NMS and compare it with that of healthy controls and sick, non-NMS foals. Study design: Prospective-clinical study. Methods: Thirty-two foals with a clinical diagnosis of NMS, 12 foals with other neonatal disorders and 10 healthy control foals were selected for the study. Heparinised blood samples were collected from each group of foals and pregnane and androgen concentrations determined using liquid chromatography mass spectrometry at 0, 24 and 48h of age. Results: Healthy foals showed a significant decrease in pregnane concentrations over the first 48h of life (P<0.01). Foals with NMS and sick, non-NMS foals had significantly increased progesterone, pregnenolone, androstenedione, dehydroepiandrosterone and epitestosterone concentrations compared with healthy foals (P<0.05). Progesterone and pregnenolone concentrations of sick, non-NMS foals decreased significantly over 48h (P<0.05), whereas concentrations in NMS foals remained increased. Conclusions and potential relevance: Pregnane concentrations of ill, neonatal foals remain increased following birth, reflecting a delayed, or interrupted, transition from intra- to extra-uterine life. Serial progesterone and pregnenolone measurement may be useful in aiding diagnosis of NMS.

AB - Reasons for performing the study: Increased levels of pregnanes have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have depressive effects in the central nervous system leading to behavioural abnormalities and altered states of consciousness in affected foals. Objectives: The aim of this study was to determine the pregnane profile of foals with NMS and compare it with that of healthy controls and sick, non-NMS foals. Study design: Prospective-clinical study. Methods: Thirty-two foals with a clinical diagnosis of NMS, 12 foals with other neonatal disorders and 10 healthy control foals were selected for the study. Heparinised blood samples were collected from each group of foals and pregnane and androgen concentrations determined using liquid chromatography mass spectrometry at 0, 24 and 48h of age. Results: Healthy foals showed a significant decrease in pregnane concentrations over the first 48h of life (P<0.01). Foals with NMS and sick, non-NMS foals had significantly increased progesterone, pregnenolone, androstenedione, dehydroepiandrosterone and epitestosterone concentrations compared with healthy foals (P<0.05). Progesterone and pregnenolone concentrations of sick, non-NMS foals decreased significantly over 48h (P<0.05), whereas concentrations in NMS foals remained increased. Conclusions and potential relevance: Pregnane concentrations of ill, neonatal foals remain increased following birth, reflecting a delayed, or interrupted, transition from intra- to extra-uterine life. Serial progesterone and pregnenolone measurement may be useful in aiding diagnosis of NMS.

KW - Foals

KW - Horse

KW - Hypoxia

KW - Neurosteroids

KW - Pregnanes

KW - Progestagens

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JO - Equine veterinary journal. Supplement

JF - Equine veterinary journal. Supplement

SN - 2042-3306

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