Abnormal development of blastocysts and blastomeres in the rhesus monkey

A. C. Enders, Andrew G Hendrickx, P. E. Binkerd

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Preimplantation stages were collected from normal rhesus monkeys by flushing of the uterine lumen. There was a high incidence of abnormal morulae and blastocysts (25%), as well as abnormal cells, and cell death in otherwise normal blastocysts. In addition to cell and nuclear fragmentation, clustering of organelles in the center of the blastomeres was a common feature in early degeneration of ova and blastomeres. Large isolated cells that lagged in cytological development were found both in large numbers in an abnormal blastocyst and as individual cells in normal blastocysts. One apparently abnormal blastocyst was composed of normal trophoblast and inner cell mass cells, but lacked desmosomes and was collapsed. The cytological study of development of the blastocyst indicated that assessment of viability of primate blastocysts by light microscopic observation of morulae and blastocyst stages is probably more fraught with difficulty than might appear from studies of common laboratory animals.

Original languageEnglish (US)
Pages (from-to)353-366
Number of pages14
JournalBiology of Reproduction
Volume26
Issue number2
DOIs
StatePublished - 1982

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Blastomeres
Blastocyst
Macaca mulatta
Morula
Desmosomes
Trophoblasts
Laboratory Animals
Organelles
Primates
Ovum
Cluster Analysis
Cell Death
Light
Incidence

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Embryology

Cite this

Abnormal development of blastocysts and blastomeres in the rhesus monkey. / Enders, A. C.; Hendrickx, Andrew G; Binkerd, P. E.

In: Biology of Reproduction, Vol. 26, No. 2, 1982, p. 353-366.

Research output: Contribution to journalArticle

Enders, A. C. ; Hendrickx, Andrew G ; Binkerd, P. E. / Abnormal development of blastocysts and blastomeres in the rhesus monkey. In: Biology of Reproduction. 1982 ; Vol. 26, No. 2. pp. 353-366.
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