Abstract
The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4334-4336 |
| Number of pages | 3 |
| Journal | Infection and Immunity |
| Volume | 65 |
| Issue number | 10 |
| State | Published - 1997 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology
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Anguita, J., Samanta, S., Barthold, S. W., & Fikrig, E. (1997). Ablation of interleukin-12 exacerbates lyme arthritis in SCID mice. Infection and Immunity, 65(10), 4334-4336.