Ablation of interleukin-12 exacerbates lyme arthritis in SCID mice

J. Anguita, S. Samanta, Stephen W Barthold, E. Fikrig

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.

Original languageEnglish (US)
Pages (from-to)4334-4336
Number of pages3
JournalInfection and Immunity
Volume65
Issue number10
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Anguita, J., Samanta, S., Barthold, S. W., & Fikrig, E. (1997). Ablation of interleukin-12 exacerbates lyme arthritis in SCID mice. Infection and Immunity, 65(10), 4334-4336.