The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.
|Original language||English (US)|
|Number of pages||3|
|Journal||Infection and Immunity|
|State||Published - 1997|
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