Abstract
The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.
Original language | English (US) |
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Pages (from-to) | 4334-4336 |
Number of pages | 3 |
Journal | Infection and Immunity |
Volume | 65 |
Issue number | 10 |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology