Ablation of interleukin-12 exacerbates lyme arthritis in SCID mice

J. Anguita; S. Samanta; Stephen W Barthold; E. Fikrig

Ablation of interleukin-12 exacerbates lyme arthritis in SCID mice

J. Anguita, S. Samanta, Stephen W Barthold, E. Fikrig

Research output: Contribution to journal › Article › peer-review

Abstract

The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.

Original language	English (US)
Pages (from-to)	4334-4336
Number of pages	3
Journal	Infection and Immunity
Volume	65
Issue number	10
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology

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title = "Ablation of interleukin-12 exacerbates lyme arthritis in SCID mice",

abstract = "The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.",

author = "J. Anguita and S. Samanta and Barthold, {Stephen W} and E. Fikrig",

year = "1997",

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AU - Fikrig, E.

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AB - The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T- cell responses leads to an exacerbation of joint inflammation.

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