Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival

Girish Venkataraman, Joo Y. Song, Alexandar Tzankov, Stephan Dirnhofer, Georg Heinze, Maria Kohl, Alexandra Traverse-Glehen, Franziska C. Eberle, Jeffrey C. Hanson, Mark A. Raffeld, Stefania Pittaluga, Elaine S. Jaffe

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) rarely express T-cell-associated antigens (TCA), but the clinical significance of this finding is uncertain. Fifty cHLs expressing any TCA on the HRS cells (TCA-cHL) were identified in two cohorts (National Cancer Institute, n 5 38; Basel, n 5 12). Diagnostic pathology data were examined in all cases with additional T-cell receptor g rearrangements (TRG) polymerase chain reaction (PCR) in a subset of cases. The outcome data were compared with a cohort of cHLs negative for TCA (n 5 272). Primary end points examined were event-free survival (EFS) and overall survival (OS). The median age in the TCA-cHL group was 40 years (range, 10-85 years). Seventy percent presented in low stage (stage I/II) at presentation with nodular sclerosis (NS) histology predominating in 80% of cases. Among the TCA, CD4 and CD2 were most commonly expressed, seen in 80.4% and 77.4% of cases, respectively. TRG PCR was negative for clonal rearrangements in 29 of 31 cases. During a median follow up of 113 months, TCA expression predicted shorter OS (adjusted hazard ratio [HRadj] 5 3.32 [95% confidence interval (CI): 1.61, 6.84]; P 5 .001) and EFS (HRadj 5 2.55 [95% CI: 1.45, 4.49]; P 5 .001). TCA-cHL often display NS histology, lack T-cell genotype, and are independently associated with significantly shorter OS and EFS compared with TCA-negative cHLs.

Original languageEnglish (US)
Pages (from-to)1795-1804
Number of pages10
JournalBlood
Volume121
Issue number10
DOIs
StatePublished - Mar 7 2013
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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    Venkataraman, G., Song, J. Y., Tzankov, A., Dirnhofer, S., Heinze, G., Kohl, M., Traverse-Glehen, A., Eberle, F. C., Hanson, J. C., Raffeld, M. A., Pittaluga, S., & Jaffe, E. S. (2013). Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival. Blood, 121(10), 1795-1804. https://doi.org/10.1182/blood-2012-06-439455