Aberrant retinal projections in congenitally deaf mice: How are phenotypic characteristics specified in development and evolution?

Deborah L. Hunt, Bryan King, Dianna M. Khan, Ebenezer N. Yamoah, Gary E. Shull, Leah Krubitzer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The contribution of sensory input to the formation of sensory system-specific (sensoritopic) connections of the thalamus and midbrain was investigated using mice lacking the Na+-K+-2Cl- cotransporter (NKCC1) or the plasma membrane Ca2+-ATPase isoform2 (PMCA2). Because these mice are congenitally deaf, the developing nervous system has no exposure to sensory-driven neural activity from the auditory system. Here we compared the retinofugal pathway in normal and congenitally deaf mice using intraocular injections of neuroanatomical tracers into each eye, and relating tracer patterns to identified thalamic nuclei and superior colliculus layers. We demonstrate that loss of such activity results in aberrant projections of the retina into nonvisual auditory structures such as the medial geniculate nucleus and the intermediate layers of the superior colliculus. These findings indicate that activity from peripheral sensory receptor arrays is necessary not only for the refinement of developing connections within a unimodal structure, but for the establishment of sensoritopic or sensory-specific connections of unimodal and multimodal structures. We hypothesize that specification of such connections may occur through the modulation of spatial expression patterns of molecules known to be involved in the development of topography of connections between brain structures, such as the ephrins, via activity-dependent, CRE-mediated gene expression.

Original languageEnglish (US)
Pages (from-to)1051-1066
Number of pages16
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume287
Issue number1
DOIs
StatePublished - Nov 2005

Fingerprint

Superior Colliculi
tracer
sensory system
tracer techniques
Member 2 Solute Carrier Family 12
mice
nervous system
Ephrins
Intraocular Injections
Geniculate Bodies
gene expression
sensory receptors
brain
Thalamic Nuclei
Ca2-transporting ATPase
thalamus
Calcium-Transporting ATPases
topography
Sensory Receptor Cells
Mesencephalon

Keywords

  • Development
  • Evolution
  • Lateral geniculate
  • Medial geniculate
  • Retinofugal

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Aberrant retinal projections in congenitally deaf mice : How are phenotypic characteristics specified in development and evolution? / Hunt, Deborah L.; King, Bryan; Khan, Dianna M.; Yamoah, Ebenezer N.; Shull, Gary E.; Krubitzer, Leah.

In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, Vol. 287, No. 1, 11.2005, p. 1051-1066.

Research output: Contribution to journalArticle

Hunt, Deborah L. ; King, Bryan ; Khan, Dianna M. ; Yamoah, Ebenezer N. ; Shull, Gary E. ; Krubitzer, Leah. / Aberrant retinal projections in congenitally deaf mice : How are phenotypic characteristics specified in development and evolution?. In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 2005 ; Vol. 287, No. 1. pp. 1051-1066.
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