Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder

J. Stoddard, S. J. Gotts, M. A. Brotman, S. Lever, D. Hsu, C. Zarate, M. Ernst, D. S. Pine, E. Leibenluft

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background Major questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas. Method We collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78). We identified brain regions with aberrant intrinsic functional connectivity in BD by first comparing voxel-wise mean global connectivity and then conducting correlation analyses. We used k-means clustering and multidimensional scaling to organize all detected regions into networks. Results Across the brain, we detected areas of dysconnectivity in both youths and adults with BD relative to HV. There were no significant age-group × diagnosis interactions. When organized by interregional connectivity, the areas of dysconnectivity in patients with BD comprised two networks: one of temporal and parietal areas involved in late stages of visual processing, and one of corticostriatal areas involved in attention, cognitive control and response generation. Conclusions These data suggest that two networks show abnormal intrinsic functional connectivity in BD. Regions in these networks have been implicated previously in BD. We observed similar dysconnectivity in youths and adults with BD. These findings provide guidance for refining models of network-based dysfunction in BD.

Original languageEnglish (US)
Pages (from-to)1509-1522
Number of pages14
JournalPsychological Medicine
Volume46
Issue number7
DOIs
StatePublished - May 1 2016
Externally publishedYes

Fingerprint

Bipolar Disorder
Age Groups
Corpus Striatum
Brain
Cluster Analysis
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • Bipolar disorder
  • children
  • functional connectivity
  • imaging
  • resting state

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology

Cite this

Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder. / Stoddard, J.; Gotts, S. J.; Brotman, M. A.; Lever, S.; Hsu, D.; Zarate, C.; Ernst, M.; Pine, D. S.; Leibenluft, E.

In: Psychological Medicine, Vol. 46, No. 7, 01.05.2016, p. 1509-1522.

Research output: Contribution to journalArticle

Stoddard, J, Gotts, SJ, Brotman, MA, Lever, S, Hsu, D, Zarate, C, Ernst, M, Pine, DS & Leibenluft, E 2016, 'Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder', Psychological Medicine, vol. 46, no. 7, pp. 1509-1522. https://doi.org/10.1017/S0033291716000143
Stoddard, J. ; Gotts, S. J. ; Brotman, M. A. ; Lever, S. ; Hsu, D. ; Zarate, C. ; Ernst, M. ; Pine, D. S. ; Leibenluft, E. / Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder. In: Psychological Medicine. 2016 ; Vol. 46, No. 7. pp. 1509-1522.
@article{c28f601a903b4e0b93e8ada8c1a3bb9b,
title = "Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder",
abstract = "Background Major questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas. Method We collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78). We identified brain regions with aberrant intrinsic functional connectivity in BD by first comparing voxel-wise mean global connectivity and then conducting correlation analyses. We used k-means clustering and multidimensional scaling to organize all detected regions into networks. Results Across the brain, we detected areas of dysconnectivity in both youths and adults with BD relative to HV. There were no significant age-group × diagnosis interactions. When organized by interregional connectivity, the areas of dysconnectivity in patients with BD comprised two networks: one of temporal and parietal areas involved in late stages of visual processing, and one of corticostriatal areas involved in attention, cognitive control and response generation. Conclusions These data suggest that two networks show abnormal intrinsic functional connectivity in BD. Regions in these networks have been implicated previously in BD. We observed similar dysconnectivity in youths and adults with BD. These findings provide guidance for refining models of network-based dysfunction in BD.",
keywords = "Bipolar disorder, children, functional connectivity, imaging, resting state",
author = "J. Stoddard and Gotts, {S. J.} and Brotman, {M. A.} and S. Lever and D. Hsu and C. Zarate and M. Ernst and Pine, {D. S.} and E. Leibenluft",
year = "2016",
month = "5",
day = "1",
doi = "10.1017/S0033291716000143",
language = "English (US)",
volume = "46",
pages = "1509--1522",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "7",

}

TY - JOUR

T1 - Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder

AU - Stoddard, J.

AU - Gotts, S. J.

AU - Brotman, M. A.

AU - Lever, S.

AU - Hsu, D.

AU - Zarate, C.

AU - Ernst, M.

AU - Pine, D. S.

AU - Leibenluft, E.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background Major questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas. Method We collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78). We identified brain regions with aberrant intrinsic functional connectivity in BD by first comparing voxel-wise mean global connectivity and then conducting correlation analyses. We used k-means clustering and multidimensional scaling to organize all detected regions into networks. Results Across the brain, we detected areas of dysconnectivity in both youths and adults with BD relative to HV. There were no significant age-group × diagnosis interactions. When organized by interregional connectivity, the areas of dysconnectivity in patients with BD comprised two networks: one of temporal and parietal areas involved in late stages of visual processing, and one of corticostriatal areas involved in attention, cognitive control and response generation. Conclusions These data suggest that two networks show abnormal intrinsic functional connectivity in BD. Regions in these networks have been implicated previously in BD. We observed similar dysconnectivity in youths and adults with BD. These findings provide guidance for refining models of network-based dysfunction in BD.

AB - Background Major questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas. Method We collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78). We identified brain regions with aberrant intrinsic functional connectivity in BD by first comparing voxel-wise mean global connectivity and then conducting correlation analyses. We used k-means clustering and multidimensional scaling to organize all detected regions into networks. Results Across the brain, we detected areas of dysconnectivity in both youths and adults with BD relative to HV. There were no significant age-group × diagnosis interactions. When organized by interregional connectivity, the areas of dysconnectivity in patients with BD comprised two networks: one of temporal and parietal areas involved in late stages of visual processing, and one of corticostriatal areas involved in attention, cognitive control and response generation. Conclusions These data suggest that two networks show abnormal intrinsic functional connectivity in BD. Regions in these networks have been implicated previously in BD. We observed similar dysconnectivity in youths and adults with BD. These findings provide guidance for refining models of network-based dysfunction in BD.

KW - Bipolar disorder

KW - children

KW - functional connectivity

KW - imaging

KW - resting state

UR - http://www.scopus.com/inward/record.url?scp=84959218996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959218996&partnerID=8YFLogxK

U2 - 10.1017/S0033291716000143

DO - 10.1017/S0033291716000143

M3 - Article

AN - SCOPUS:84959218996

VL - 46

SP - 1509

EP - 1522

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 7

ER -