Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

Grace O. Mizuno, Yinxue Wang, Guilai Shi, Yizhi Wang, Junqing Sun, Stelios Papadopoulos, Gerard J. Broussard, Elizabeth K. Unger, Wenbin Deng, Jason Weick, Anita Bhattacharyya, Chao-Yin Chen, Guoqiang Yu, Loren L. Looger, Lin Tian

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

To understand how Down syndrome (DS) affects neural networks, Mizuno et al. used a DS-patient-derived stem cell model and calcium imaging to investigate the functional defects of DS astrocytes and their effects on neuronal excitability. Their study reveals that DS astroglia exhibited more frequent spontaneous calcium fluctuations, which impair neuronal excitability.

Original languageEnglish (US)
Pages (from-to)355-365
Number of pages11
JournalCell Reports
Volume24
Issue number2
DOIs
StatePublished - Jul 10 2018

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Keywords

  • astrocyte-neuron interaction
  • astrocytes
  • calcium imaging
  • Down syndrome
  • human IPSCs
  • S100B

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mizuno, G. O., Wang, Y., Shi, G., Wang, Y., Sun, J., Papadopoulos, S., Broussard, G. J., Unger, E. K., Deng, W., Weick, J., Bhattacharyya, A., Chen, C-Y., Yu, G., Looger, L. L., & Tian, L. (2018). Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Reports, 24(2), 355-365. https://doi.org/10.1016/j.celrep.2018.06.033