Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

Grace O. Mizuno, Yinxue Wang, Guilai Shi, Yizhi Wang, Junqing Sun, Stelios Papadopoulos, Gerard J. Broussard, Elizabeth K. Unger, Wenbin Deng, Jason Weick, Anita Bhattacharyya, Chao-Yin Chen, Guoqiang Yu, Loren L. Looger, Lin Tian

Research output: Contribution to journalArticle

Abstract

To understand how Down syndrome (DS) affects neural networks, Mizuno et al. used a DS-patient-derived stem cell model and calcium imaging to investigate the functional defects of DS astrocytes and their effects on neuronal excitability. Their study reveals that DS astroglia exhibited more frequent spontaneous calcium fluctuations, which impair neuronal excitability.

LanguageEnglish (US)
Pages355-365
Number of pages11
JournalCell Reports
Volume24
Issue number2
DOIs
StatePublished - Jul 10 2018

Fingerprint

Calcium Signaling
Down Syndrome
Stem cells
Astrocytes
Stem Cells
Calcium
Neural networks
Imaging techniques
Defects

Keywords

  • astrocyte-neuron interaction
  • astrocytes
  • calcium imaging
  • Down syndrome
  • human IPSCs
  • S100B

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. / Mizuno, Grace O.; Wang, Yinxue; Shi, Guilai; Wang, Yizhi; Sun, Junqing; Papadopoulos, Stelios; Broussard, Gerard J.; Unger, Elizabeth K.; Deng, Wenbin; Weick, Jason; Bhattacharyya, Anita; Chen, Chao-Yin; Yu, Guoqiang; Looger, Loren L.; Tian, Lin.

In: Cell Reports, Vol. 24, No. 2, 10.07.2018, p. 355-365.

Research output: Contribution to journalArticle

Mizuno, GO, Wang, Y, Shi, G, Wang, Y, Sun, J, Papadopoulos, S, Broussard, GJ, Unger, EK, Deng, W, Weick, J, Bhattacharyya, A, Chen, C-Y, Yu, G, Looger, LL & Tian, L 2018, 'Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model' Cell Reports, vol. 24, no. 2, pp. 355-365. https://doi.org/10.1016/j.celrep.2018.06.033
Mizuno, Grace O. ; Wang, Yinxue ; Shi, Guilai ; Wang, Yizhi ; Sun, Junqing ; Papadopoulos, Stelios ; Broussard, Gerard J. ; Unger, Elizabeth K. ; Deng, Wenbin ; Weick, Jason ; Bhattacharyya, Anita ; Chen, Chao-Yin ; Yu, Guoqiang ; Looger, Loren L. ; Tian, Lin. / Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. In: Cell Reports. 2018 ; Vol. 24, No. 2. pp. 355-365.
@article{7664ffab26864c218753d05fc10f5052,
title = "Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model",
abstract = "To understand how Down syndrome (DS) affects neural networks, Mizuno et al. used a DS-patient-derived stem cell model and calcium imaging to investigate the functional defects of DS astrocytes and their effects on neuronal excitability. Their study reveals that DS astroglia exhibited more frequent spontaneous calcium fluctuations, which impair neuronal excitability.",
keywords = "astrocyte-neuron interaction, astrocytes, calcium imaging, Down syndrome, human IPSCs, S100B",
author = "Mizuno, {Grace O.} and Yinxue Wang and Guilai Shi and Yizhi Wang and Junqing Sun and Stelios Papadopoulos and Broussard, {Gerard J.} and Unger, {Elizabeth K.} and Wenbin Deng and Jason Weick and Anita Bhattacharyya and Chao-Yin Chen and Guoqiang Yu and Looger, {Loren L.} and Lin Tian",
year = "2018",
month = "7",
day = "10",
doi = "10.1016/j.celrep.2018.06.033",
language = "English (US)",
volume = "24",
pages = "355--365",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

AU - Mizuno, Grace O.

AU - Wang, Yinxue

AU - Shi, Guilai

AU - Wang, Yizhi

AU - Sun, Junqing

AU - Papadopoulos, Stelios

AU - Broussard, Gerard J.

AU - Unger, Elizabeth K.

AU - Deng, Wenbin

AU - Weick, Jason

AU - Bhattacharyya, Anita

AU - Chen, Chao-Yin

AU - Yu, Guoqiang

AU - Looger, Loren L.

AU - Tian, Lin

PY - 2018/7/10

Y1 - 2018/7/10

N2 - To understand how Down syndrome (DS) affects neural networks, Mizuno et al. used a DS-patient-derived stem cell model and calcium imaging to investigate the functional defects of DS astrocytes and their effects on neuronal excitability. Their study reveals that DS astroglia exhibited more frequent spontaneous calcium fluctuations, which impair neuronal excitability.

AB - To understand how Down syndrome (DS) affects neural networks, Mizuno et al. used a DS-patient-derived stem cell model and calcium imaging to investigate the functional defects of DS astrocytes and their effects on neuronal excitability. Their study reveals that DS astroglia exhibited more frequent spontaneous calcium fluctuations, which impair neuronal excitability.

KW - astrocyte-neuron interaction

KW - astrocytes

KW - calcium imaging

KW - Down syndrome

KW - human IPSCs

KW - S100B

UR - http://www.scopus.com/inward/record.url?scp=85049346171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049346171&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2018.06.033

DO - 10.1016/j.celrep.2018.06.033

M3 - Article

VL - 24

SP - 355

EP - 365

JO - Cell Reports

T2 - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 2

ER -