Aberrant amygdala intrinsic functional connectivity distinguishes youths with bipolar disorder from those with severe mood dysregulation

Joel Stoddard, Derek Hsu, Richard C. Reynolds, Melissa A. Brotman, Monique Ernst, Daniel S. Pine, Ellen Leibenluft, Daniel P. Dickstein

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

It remains unclear the degree to which youths with episodic mania (bipolar disorder; BD) vs. those with chronic, severe irritability (severe mood dysregulation, SMD) should be placed in similar or distinct diagnostic groups. Addressing this clinically meaningful question requires greater understanding of the neural alterations underlying both disorders. We evaluated resting state functional magnetic resonance imaging data of 53 youths (14 BD, 20 healthy volunteers (HV), and 19 SMD, ages 9-18.5 years). Seed regions of interest were the bilateral basolateral, superficial and centromedial amygdala, defined using the Juelich probabilistic atlas. We found a significant between-group difference in functional connectivity between the left basolateral amygdala and the medial aspect of the left frontal pole plus the posterior cingulate/precuneus. This finding was driven by hyperconnectivity among BD vs. HV or SMD youths. As with earlier data, these findings suggest that the pathophysiology of BD and SMD may differ.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalPsychiatry Research - Neuroimaging
Volume231
Issue number2
DOIs
StatePublished - Feb 28 2015
Externally publishedYes

Keywords

  • Bipolar disorder
  • Child
  • Functional connectivity
  • Irritability
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Fingerprint Dive into the research topics of 'Aberrant amygdala intrinsic functional connectivity distinguishes youths with bipolar disorder from those with severe mood dysregulation'. Together they form a unique fingerprint.

  • Cite this