Abdominal surgery induces c-fos expression in the nucleus of the solitary tract in the rat

T. T. Zittel, R. De Giorgio, N. C. Brecha, C. Sternini, Helen E Raybould

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In a model of abdominal surgery, which consisted of cecal manipulation and induces postoperative ileus in rats, we studied c-fos protein expression in the nucleus of the solitary tract (NTS), the spinal cord and dorsal root ganglia. Abdominal surgery resulted in a significantly higher number of c-fos protein immunoreactive cells in the NTS compared with controls but not in dorsal root ganglia and resulted in only a few scattered cells in the spinal cord. Neurons expressing c-fos protein were concentrated in NTS regions where cecal afferents terminate. These findings support the hypothesis that sensory vagal pathways partly mediate abdominal surgery-induced postoperative ileus.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalNeuroscience Letters
Volume159
Issue number1-2
DOIs
StatePublished - Sep 3 1993

Fingerprint

Proto-Oncogene Proteins c-fos
Solitary Nucleus
Ileus
Spinal Ganglia
Spinal Cord
Spinal Nerve Roots
Neurons

Keywords

  • Abdominal surgery
  • C-fos protein
  • Nucleus of solitary tract
  • Postoperative ileus
  • Rat
  • Vagal afferent pathway

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Abdominal surgery induces c-fos expression in the nucleus of the solitary tract in the rat. / Zittel, T. T.; De Giorgio, R.; Brecha, N. C.; Sternini, C.; Raybould, Helen E.

In: Neuroscience Letters, Vol. 159, No. 1-2, 03.09.1993, p. 79-82.

Research output: Contribution to journalArticle

Zittel, T. T. ; De Giorgio, R. ; Brecha, N. C. ; Sternini, C. ; Raybould, Helen E. / Abdominal surgery induces c-fos expression in the nucleus of the solitary tract in the rat. In: Neuroscience Letters. 1993 ; Vol. 159, No. 1-2. pp. 79-82.
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