Abstract
Purpose: HIV-infected patients show a high incidence of abdominal disease. This investigation was made to determine whether abdominal CT provided prognostically relevant information in these patients. Material and Methods: Images from 533 abdominal CT examinations in 339 HIV-infected patients were retrospectively reviewed for signs of abdominal disease, and correlated with clinical data and survival rates. The Kaplan-Meier analysis and rank testing of survival, and proportional hazards regression were used to define prognostic clinical and imaging findings. Results: Of the 339 patients, 278 (82%) showed abnormal abdominal findings on CT. Median survival was 29 months. Of the imaging findings, hepatic masses (n=11), pathologically enlarged lymph nodes (n=48), and ascites (n=7) were associated with poor survival, giving a median survival of respectively 13 months, 15 months, and less than 1 month. These three features showed no association with CD4+-T-lymphocyte count or CDC category. Main determinants of survival were a low CD4+-T-lymphocyte count, and certain abnormal CT findings. Splenomegaly (n=147), hepatomegaly (n=144), and lymphadenopathy (n=111) were the most common abdominal findings on CT but lacked prognostic relevance. Conclusion: Abdominal CT offered prognostic implications in HIV-infected patients and might serve in risk stratification in selected patients. CT features such as hepatic masses, grossly enlarged lymph nodes, or ascites indicate advanced immunosuppression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 970-977 |
| Number of pages | 8 |
| Journal | Acta Radiologica |
| Volume | 38 |
| Issue number | 6 |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- Abdomen, survival rate
- Acquired immunodeficiency syndrome (AIDS), CT
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Abdominal CT features and survival in acquired immunodeficiency. / Knollmann, Friedrich D; Mäurer, J.; Grünewald, T.; Schedel, H.; Vogl, T. J.; Pohle, H. D.; Felix, R.
In: Acta Radiologica, Vol. 38, No. 6, 1997, p. 970-977.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abdominal CT features and survival in acquired immunodeficiency
AU - Knollmann, Friedrich D
AU - Mäurer, J.
AU - Grünewald, T.
AU - Schedel, H.
AU - Vogl, T. J.
AU - Pohle, H. D.
AU - Felix, R.
PY - 1997
Y1 - 1997
N2 - Purpose: HIV-infected patients show a high incidence of abdominal disease. This investigation was made to determine whether abdominal CT provided prognostically relevant information in these patients. Material and Methods: Images from 533 abdominal CT examinations in 339 HIV-infected patients were retrospectively reviewed for signs of abdominal disease, and correlated with clinical data and survival rates. The Kaplan-Meier analysis and rank testing of survival, and proportional hazards regression were used to define prognostic clinical and imaging findings. Results: Of the 339 patients, 278 (82%) showed abnormal abdominal findings on CT. Median survival was 29 months. Of the imaging findings, hepatic masses (n=11), pathologically enlarged lymph nodes (n=48), and ascites (n=7) were associated with poor survival, giving a median survival of respectively 13 months, 15 months, and less than 1 month. These three features showed no association with CD4+-T-lymphocyte count or CDC category. Main determinants of survival were a low CD4+-T-lymphocyte count, and certain abnormal CT findings. Splenomegaly (n=147), hepatomegaly (n=144), and lymphadenopathy (n=111) were the most common abdominal findings on CT but lacked prognostic relevance. Conclusion: Abdominal CT offered prognostic implications in HIV-infected patients and might serve in risk stratification in selected patients. CT features such as hepatic masses, grossly enlarged lymph nodes, or ascites indicate advanced immunosuppression.
AB - Purpose: HIV-infected patients show a high incidence of abdominal disease. This investigation was made to determine whether abdominal CT provided prognostically relevant information in these patients. Material and Methods: Images from 533 abdominal CT examinations in 339 HIV-infected patients were retrospectively reviewed for signs of abdominal disease, and correlated with clinical data and survival rates. The Kaplan-Meier analysis and rank testing of survival, and proportional hazards regression were used to define prognostic clinical and imaging findings. Results: Of the 339 patients, 278 (82%) showed abnormal abdominal findings on CT. Median survival was 29 months. Of the imaging findings, hepatic masses (n=11), pathologically enlarged lymph nodes (n=48), and ascites (n=7) were associated with poor survival, giving a median survival of respectively 13 months, 15 months, and less than 1 month. These three features showed no association with CD4+-T-lymphocyte count or CDC category. Main determinants of survival were a low CD4+-T-lymphocyte count, and certain abnormal CT findings. Splenomegaly (n=147), hepatomegaly (n=144), and lymphadenopathy (n=111) were the most common abdominal findings on CT but lacked prognostic relevance. Conclusion: Abdominal CT offered prognostic implications in HIV-infected patients and might serve in risk stratification in selected patients. CT features such as hepatic masses, grossly enlarged lymph nodes, or ascites indicate advanced immunosuppression.
KW - Abdomen, survival rate
KW - Acquired immunodeficiency syndrome (AIDS), CT
UR - http://www.scopus.com/inward/record.url?scp=0031278441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031278441&partnerID=8YFLogxK
M3 - Article
C2 - 9394651
AN - SCOPUS:0031278441
VL - 38
SP - 970
EP - 977
JO - Acta Radiologica
JF - Acta Radiologica
SN - 0284-1851
IS - 6
ER -