A voxel-based morphometry comparison of regional gray matter between fragile X syndrome and autism

Lisa B. Wilson, Jason R. Tregellas, Randi J Hagerman, Sally J Rogers, Donald C. Rojas

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The phenotypic association between fragile X syndrome (FXS) and autism is well established, but no studies have directly compared whole-brain anatomy between the two disorders. We performed voxel-based morphometry analyses of magnetic resonance imaging (MRI) scans on 10 individuals with FXS, 10 individuals with autism, and 10 healthy comparison subjects to identify volumetric changes in each disorder. Regional gray matter volumes within frontal, parietal, temporal, and cingulate gyri, as well as in the caudate nuclei and cerebellum, were larger in the FXS group relative to the autism group. In addition, volume increases in FXS were observed in frontal gyri and caudate nuclei compared to controls. The autism group exhibited volume increases in frontal and temporal gyri relative to the FXS group, and no volume increases relative to controls. Volumetric deficits relative to controls were observed in regions of the cerebellum for both groups, with additional deficits in parietal and temporal gyri for the FXS group. Our caudate nuclei and frontal gyri results may implicate dysfunction of frontostriatal circuitry in FXS. Cerebellar deficits suggest atypical development of the cerebellum contributing to the phenotype of both disorders, but further imply that unique cerebellar regions contribute to the phenotype of each disorder.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume174
Issue number2
DOIs
StatePublished - Nov 30 2009

Fingerprint

Fragile X Syndrome
Autistic Disorder
Caudate Nucleus
Temporal Lobe
Cerebellum
Phenotype
Gyrus Cinguli
Gray Matter
Anatomy
Healthy Volunteers
Magnetic Resonance Imaging
Brain

Keywords

  • Caudate nucleus
  • Cerebellum
  • Frontostriatal
  • Inferior frontal gyrus
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

A voxel-based morphometry comparison of regional gray matter between fragile X syndrome and autism. / Wilson, Lisa B.; Tregellas, Jason R.; Hagerman, Randi J; Rogers, Sally J; Rojas, Donald C.

In: Psychiatry Research - Neuroimaging, Vol. 174, No. 2, 30.11.2009, p. 138-145.

Research output: Contribution to journalArticle

@article{8f13cc74419841f3967ed3f15259d907,
title = "A voxel-based morphometry comparison of regional gray matter between fragile X syndrome and autism",
abstract = "The phenotypic association between fragile X syndrome (FXS) and autism is well established, but no studies have directly compared whole-brain anatomy between the two disorders. We performed voxel-based morphometry analyses of magnetic resonance imaging (MRI) scans on 10 individuals with FXS, 10 individuals with autism, and 10 healthy comparison subjects to identify volumetric changes in each disorder. Regional gray matter volumes within frontal, parietal, temporal, and cingulate gyri, as well as in the caudate nuclei and cerebellum, were larger in the FXS group relative to the autism group. In addition, volume increases in FXS were observed in frontal gyri and caudate nuclei compared to controls. The autism group exhibited volume increases in frontal and temporal gyri relative to the FXS group, and no volume increases relative to controls. Volumetric deficits relative to controls were observed in regions of the cerebellum for both groups, with additional deficits in parietal and temporal gyri for the FXS group. Our caudate nuclei and frontal gyri results may implicate dysfunction of frontostriatal circuitry in FXS. Cerebellar deficits suggest atypical development of the cerebellum contributing to the phenotype of both disorders, but further imply that unique cerebellar regions contribute to the phenotype of each disorder.",
keywords = "Caudate nucleus, Cerebellum, Frontostriatal, Inferior frontal gyrus, Magnetic resonance imaging",
author = "Wilson, {Lisa B.} and Tregellas, {Jason R.} and Hagerman, {Randi J} and Rogers, {Sally J} and Rojas, {Donald C.}",
year = "2009",
month = "11",
day = "30",
doi = "10.1016/j.pscychresns.2009.04.013",
language = "English (US)",
volume = "174",
pages = "138--145",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - A voxel-based morphometry comparison of regional gray matter between fragile X syndrome and autism

AU - Wilson, Lisa B.

AU - Tregellas, Jason R.

AU - Hagerman, Randi J

AU - Rogers, Sally J

AU - Rojas, Donald C.

PY - 2009/11/30

Y1 - 2009/11/30

N2 - The phenotypic association between fragile X syndrome (FXS) and autism is well established, but no studies have directly compared whole-brain anatomy between the two disorders. We performed voxel-based morphometry analyses of magnetic resonance imaging (MRI) scans on 10 individuals with FXS, 10 individuals with autism, and 10 healthy comparison subjects to identify volumetric changes in each disorder. Regional gray matter volumes within frontal, parietal, temporal, and cingulate gyri, as well as in the caudate nuclei and cerebellum, were larger in the FXS group relative to the autism group. In addition, volume increases in FXS were observed in frontal gyri and caudate nuclei compared to controls. The autism group exhibited volume increases in frontal and temporal gyri relative to the FXS group, and no volume increases relative to controls. Volumetric deficits relative to controls were observed in regions of the cerebellum for both groups, with additional deficits in parietal and temporal gyri for the FXS group. Our caudate nuclei and frontal gyri results may implicate dysfunction of frontostriatal circuitry in FXS. Cerebellar deficits suggest atypical development of the cerebellum contributing to the phenotype of both disorders, but further imply that unique cerebellar regions contribute to the phenotype of each disorder.

AB - The phenotypic association between fragile X syndrome (FXS) and autism is well established, but no studies have directly compared whole-brain anatomy between the two disorders. We performed voxel-based morphometry analyses of magnetic resonance imaging (MRI) scans on 10 individuals with FXS, 10 individuals with autism, and 10 healthy comparison subjects to identify volumetric changes in each disorder. Regional gray matter volumes within frontal, parietal, temporal, and cingulate gyri, as well as in the caudate nuclei and cerebellum, were larger in the FXS group relative to the autism group. In addition, volume increases in FXS were observed in frontal gyri and caudate nuclei compared to controls. The autism group exhibited volume increases in frontal and temporal gyri relative to the FXS group, and no volume increases relative to controls. Volumetric deficits relative to controls were observed in regions of the cerebellum for both groups, with additional deficits in parietal and temporal gyri for the FXS group. Our caudate nuclei and frontal gyri results may implicate dysfunction of frontostriatal circuitry in FXS. Cerebellar deficits suggest atypical development of the cerebellum contributing to the phenotype of both disorders, but further imply that unique cerebellar regions contribute to the phenotype of each disorder.

KW - Caudate nucleus

KW - Cerebellum

KW - Frontostriatal

KW - Inferior frontal gyrus

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=71749109795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71749109795&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2009.04.013

DO - 10.1016/j.pscychresns.2009.04.013

M3 - Article

C2 - 19853418

AN - SCOPUS:71749109795

VL - 174

SP - 138

EP - 145

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 2

ER -